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neural communication. electrical within, chemical between. vesicles, exocytosis, & binding. the big picture. ACTION POTENTIAL (voltage-gated channels). GRADED POTENTIALS EPSP/IPSP (ligand-gated channels). graded potentials & membrane. sodium (Na+) potassium (K+) chloride (Cl-).
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neural communication electrical within, chemical between
the big picture ACTION POTENTIAL (voltage-gated channels) GRADED POTENTIALS EPSP/IPSP (ligand-gated channels)
graded potentials & membrane sodium (Na+) potassium (K+) chloride (Cl-) channels on dendrites
EPSP & IPSP sodium (Na+) potassium (K+) chloride (Cl-) So, how are EPSPs and IPSPs created?
ELECTRICAL EVENT #1 LEADS TO ELECTRICAL EVENT #2 CHEMICAL EVENT LEADS TO ELECTRICAL EVENT #1 (EPSPS & IPSPS cause AP) (Neurotransmitters cause EPSPs & IPSPs) voltage-gated channels ligand-gated channels
creating EPSP/IPSP Neurotransmitters cause EPSPs & IPSPs. EPSP IPSP
receptors & channels voltage-gated action potential & neurotransmitter release ligand-gated graded potentials
neurotransmitters glutamate (+) vs GABA (-) acetylcholine (Ach) serotonin (5-HT) dopamine (DA) epinephrine (E) & norepinephrine (NE) about receptor subtypes…
inactivating NTs • reuptake • enzymatic breakdown • diffusion
ligand-gated channels effects after binding IONOTROPIC - fast METABOTROPIC - cascade of events requiring energy - alters structure of the cell - turn on/off genes