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Project proposal

Project proposal. Alexey Tokarev. Regulation of plug / thrombus growth. Experiment. Blood flow. Falati et al (2002). fibrin. platelets. platelets+fibrin. Lagrangian model. Tosenberger et al. 2012. Rus. J Num. Anal. Math. Model. Ca 2+ transient oscillations.

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Project proposal

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  1. Project proposal Alexey Tokarev

  2. Regulation of plug/ thrombus growth • Experiment Blood flow Falati et al (2002) fibrin platelets platelets+fibrin • Lagrangian model Tosenberger et al. 2012. Rus. J Num. Anal. Math. Model.

  3. Ca2+ transient oscillations Mazzucato et al., 2002

  4. Platelet activation through Gq GPCRStep 1. Reproduce published model results Purvis, Blood, 2008

  5. ODE simulation

  6. Stochastic simulations

  7. Step 2. Find a dose-response curve (rule) for every subsystem to build a reduced model

  8. Plan / progress • Got xml file from the author • Import into SBtollbox in Matlab (install SBtbx and libSBML) • Fix bugs • Export as correct xml into VCell • ODE formulation • Stochastic formulation • Separate inspection of building blocks

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