1 / 8

Late-outcomes of TB-IRIS

Late-outcomes of TB-IRIS. William Worodria , MBChB , MMed , PhD Senior EDCTP Fellow Infectious Disease Institute, Kampala, Uganda Mulago Hospital & Complex, Kampala, Uganda. Study objective.

masako
Download Presentation

Late-outcomes of TB-IRIS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Late-outcomes of TB-IRIS William Worodria, MBChB, MMed, PhD Senior EDCTP Fellow Infectious Disease Institute, Kampala, Uganda Mulago Hospital & Complex, Kampala, Uganda The Rainbow of IRIS in HIV, 26th July 2012

  2. Study objective To determine if there are differences in treatment outcomes between TB-HIV co-infected patients with and without TB-IRIS: • CD4 changes with treatment • Mortality • Loss to follow up The Rainbow of IRIS in HIV, 26th July 2012

  3. Methodology Site: Mulago National TB treatment centre Design: Case-control design. Inclusion criteria: • ART naïve adult patients co-infected with TB-HIV started on HAART (CD4<250) Exclusion criteria: • No treatment supporter • Severe liver/renal abnormalities Cases: patients with TB-IRIS Controls: patients without TB-IRIS -matched by baseline CD4 count (1:2) The Rainbow of IRIS in HIV, 26th July 2012

  4. Results From December 2007 - July 2010, we enrolled 254 patients with TB-HIV starting ART We identified: • 61 cases of TB-IRIS and • 122 controls (no TB-IRIS) The Rainbow of IRIS in HIV, 26th July 2012

  5. Median CD4 counts of patients co-infected with TB-HIV on antiretroviral therapy The Rainbow of IRIS in HIV, 26th July 2012

  6. Treatment outcomes Mortality: 6 (10%) patients with TB-IRIS died vs 18 (15%) without TB-IRIS ORmortality = 0.60, 95% CI 0.21-1.70, (p= 0.34) Loss to Follow up: 5 (8.2%) patients with TB-IRIS vs 10 (8.2%) without were lost to follow up ORloss2fu = 1.00, 95% CI 0.33- 3.04, (p=1.00) The Rainbow of IRIS in HIV, 26th July 2012

  7. Conclusion TB-IRIS in this study with a small sample size had no impact on outcomes The Rainbow of IRIS in HIV, 26th July 2012

  8. Acknowledgments Prof. R Colebunders Joseph Sempa All patients M-MJAP The Rainbow of IRIS in HIV, 26th July 2012

More Related