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Rhythmic Fluctuations in the Body and their Interactions. Kuo, T.B.J. , MD, PhD 郭博昭博士. 國立陽明大學醫學系藥理學科 Department of Pharmacology, Faculty of Medicine, National Yang-Ming University. Rhythms in the Body. Respiratory related rhythm Frequency: synchronized with respiration
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Rhythmic Fluctuations in the Body and their Interactions Kuo, T.B.J. , MD, PhD 郭博昭博士 國立陽明大學醫學系藥理學科 Department of Pharmacology, Faculty of Medicine,National Yang-Ming University
Rhythms in the Body • Respiratory related rhythm • Frequency: synchronized with respiration • Vasomotor related rhythm • Frequency: 0.1 Hz or 10 seconds
Fourier Transform Tachogram Transfer Function Analysis
Fourier Transform transform data from TIME domain to FREQUENCY domain Discrete Fourier Transform (DFT) Fast Fourier Transform (FFT)
TRANSFER FUNCTION: H(x) transfer relationship from one signal to the other signal, including magnitude (gain) and phase TRANSFERFUNCTION OUTPUT INPUT HELLO H1(x) HELLO H2(x) ELLOH HELLO
TRANSFER FUNCTION IN HUMAN BODY H(x) BP HEART RATE VENOUSRETURN STROKEVOLUME H(x) LUNGVOLUME RESPIRATORYRATE H(x) PATELLAR TENDON TENSION QUADRICEPSTENSION H(x)
Transfer function analysis of ventilatory influence on systemic arterial pressure in the rat [18] Arterial Pressure Respiration HBR(x)
Selective activation of vasomotor component of SAP spectrum by broad-band stimulation of nucleus reticularis ventrolateralis in the rat [21] Brain Stem Vasomotor Center Arterial Pressure HBS(x)
Auto- and cross-spectral analysis of cardiovascular fluctuations during pentobarbital anesthesia in the rat [16] HHB(x) Baroreflex Arterial Pressure Heart Rate
Frequency domain analysis of cerebral blood velocity and its correlation with arterial blood pressure [25] HCB(x) Autoregulation Arterial Pressure Cerebral Blood Flow
Respiratory related rhythm Cerebral Blood Flow Brain Stem Baroreceptor [16] Spinal Cord Respiration [27] Peripheral Resistance Stroke Volume Heart Rate [25] [18] Arterial Pressure
Vasomotor related rhythm Cerebral Blood Flow Brain Stem [24] Baroreceptor [16] Spinal Cord Respiration Peripheral Resistance Stroke Volume Heart Rate Autoregulation [21] [25] Arterial Pressure