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The European HealthGrid Initiative

The European HealthGrid Initiative. e-Health and the Grid: Projects and Prospects in the European Union. NEC 2005 40 years. Tony Solomonides on behalf of The HealthGrid Association. Issues and Projects. What is a ‘healthgrid’? combines Grid and e-Science ideas

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The European HealthGrid Initiative

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  1. The EuropeanHealthGrid Initiative e-Health and the Grid: Projects and Prospects in the European Union NEC 2005 40 years Tony Solomonides on behalf of The HealthGrid Association

  2. Issues and Projects • What is a ‘healthgrid’? • combines Grid and e-Science ideas • oriented to biomedical advances • supports evidence-based practice • What projects? • imaging for diagnosis and treatment • simulation for treatment guidance • bioinformatics for biomedicine • legal, ethical, security and trust issues NEC 2005

  3. History • HealthGrid 2003 – Lyon, Jan 03 • HealthGrid Association incorporated • HealthGrid 2004 – Clermont-Ferrand, Jan 04 • HealthGrid ‘White Paper’, June 04 • HealthGrid 2005 – Oxford, Apr 05 • FP6 Project ‘SHARE’ – December 05 • HealthGrid 2006 – Valencia, June 06 NEC 2005

  4. Principal Themes • Integration • Levels of life & knowledge: correspondence & convergence • Issues of ethics and trust • Services on grid infrastructure NEC 2005

  5. Principal Theme 1 • Integration • medical and bioinformatics • patient information and medical knowledge • ‘gold standard’ evidence and practice-based evidence • patient data – images, labs, history • models of the human body • legal, ethical, social, trust issues NEC 2005

  6. Example 1Knowledge Grid • EU project to prototype a pan-European distributed databaseof mammographic images using Grid Technologies. • Aim: To provide a demonstrator for use in epidemiological studies, quality control and validation of computer aided detection algorithms. NEC 2005

  7. Workstations Workstations MG W/s (‘‘MAS’’) GRID VPN Udine CERN MammoGrid Data MammoGrid Data GridBox High Security Level MammoGrid Data MammoGrid Data GridBox GridBox Cambridge Oxford MG W/s (‘‘MAS’’) Grid Architecture NEC 2005

  8. Grids and Imaging 1 • Diagnosis • comparison, ‘find-one-like-it’ • Epidemiology • virtual databases • significant statistics • Therapy planning • targetting, implantation, surgery • Problems of heterogeneity • Security Issues NEC 2005

  9. Grids and Imaging 2 • Service Oriented Architecture • grid services can deal with heterogeneity • grid services can be used to plan workflow • examples include annotation, detection, analysis, registration, aggregation and visualization services • Optimistically … • legal, ethical, social and trust negotiations may be implemented through services NEC 2005

  10. Bio-numeric modelling Medical Expertise Legal Aspects Grid Software Simulation &Imaging Example 2Computational Grid • Secure & lawful Grid provision of medical services • Build 6 Grid-enabled medical prototype applications • Build suitable middleware on top of common standards • Install and evaluate a GEMSS test-bed • Anticipate privacy, security & other legal concerns Taken from Gerhard Engelbrecht NEC 2005

  11. Applications Taken from Gerhard Engelbrecht NEC 2005

  12. Principal Theme 2 • Levels of life • Levels of knowledge • Correspondence and convergence • medicine and genomics • ‘molecular medicine’ • ‘individualized healthcare’ NEC 2005

  13. PATHOLOG I ES Population I NB I OMED Public Health Informatics Genomic Epidemiology Disease Medical Informatics Patient Pharmacogenetics Tissue, organ Molecular and Image-based diagnosis Medical Imaging Molecular, genetic Bioinformatics Bio-social being & pathology Taken from Fernando Martín-Sánchez NEC 2005

  14. An example: • Integration of clinical and genetic info from heterogeneous remote databases • A vocabulary server that aims to combine existing terminology systems in Medicine and Genetics • Novel framework for clinicians to locate, search, access, retrieve and use genomic information in patient care Taken from Fernando Martín-Sánchez NEC 2005

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  18. Principal Theme 3 • ‘LEST’ Issues • use of data in care and in research • data provenance • privacy / confidentiality • security • national / EU legal framework • … extending the concept of a ‘virtual organization’ • & building negotiation into the infrastructure NEC 2005

  19. GRIDs and Privacy • Good reasons for talking about privacy here and now! • The HealthGrid promises access to large amounts of heterogeneous distributed data • Health related information is very sensitive and prone to abuse • Privacy impacts society as a whole(e.g. loan applications, insurance, scholarship, ...) • Privacy violation is irreversible • Confidential information can never be considered confidential again, once it was out in the open • Grid and Privacy Enhancing Technology exist and are usedThey could both benefit from early integration Adapted from Georges de Moor and Brecht Claerhout NEC 2005

  20. Sharing of Healthcare Data Local Database • Local Databases: • Nominative records (e.g. patient treatment) • Privacy protected DBs • Privacy Protecting Interface (PETs): • Locally controlled • Pseudonymisation • Content filtering and transformation • Query evaluation (restriction) Privacy Protecting Interface Data Access through the Grid Adapted from Georges de Moor and Brecht Claerhout NEC 2005

  21. Principal theme 4 • A Grid Infrastructure for Health Applications • Technology attitude • To build on what already exists • To build only what is necessary NEC 2005

  22. Layered Grid Technologies Data Abstraction • Data mining, visualisation, simulation, problem solving methods/environments … Knowledge Grid • Metadata, middleware, intelligent retrieval, information modelling, warehousing, workflow … Information Grid • Distributed databases, streaming, near-line storage, large objects, access mechanisms, data staging … Data Grid Data Control NEC 2005

  23. A Grid Infrastructure for Health Applications • To address the problems of • integration of multi-level medical data, and • the exploitation of its intrinsic knowledge • through a health-specific grid Infrastructure and a set of grid applications for health. • To integrate • grid infrastructures, • health-related grid components, and • pilot applications • to provide a workbench for medical and clinical support. • To develop components to link • the available expertise, • data, and • resources. • to demonstrate the benefits through pilots in epidemiology and personalised healthcare. NEC 2005

  24. Benefits Expected • At the patient level • Personalised healthcare, e.g. through simulation in therapy. • Improvement in the effectiveness of health policies through epidemiological studies. • At the medical professional level • Development of federated databases and collaborative communities. • Development of services to support diagnosis and therapy in day-to-day work. • At the IT Level • A workbench for the development of tools and services towards specific features of healthcare IT. NEC 2005

  25. ’89-’91 ’91-’94 ’94-’98 ’98-’02 20 Years of eHealth R&D Context NEXT10 years (2003-2014) PAST10 years (1991-2002) ’02-’06 Research activities (200 Mil. €) Regional Health Info Networks Home-care systems Personal Health Systems • Biomedical Informatics • informatics for Genomic Medicine • Virtual Physiological Human Computer Applications for Doctors Telemedicine systems and services @ • HealthGrid Budget100M € Budget140M € Budget200M € Personal health systems (Wearable & Implantable) based on new biosensors Decision Support Syst./Patient Safety Budget20M € Projects63 Projects158 Projects125 Projects30 ResultsAIM Community Results1st batch of Products ResultsEU Health Telematics Industry Currently preparing activities for ’06-’10 ResultsFeasibility Study www.cordis.lu/ist/directorate_c/ehealth/index.html NEC 2005

  26. EC - ICT for Health Current Activities and Plans Basic research Biomedical informatics III HealthGrid Applied/ Industrial R&D Decision Support Systems II Personal Health Systems (wearables) General issues EHR, Security, Interoperability Health info networks & services I EHR & interoperability Support to eHealth “Action Plan” Deployment 5 years 10 years 15 years NEC 2005 Time to results

  27. eHealth ERA CISTRANA - IST ERA III II I SYMBIOMATICSBMI ERA Pilot I2HEALTH Identification doctors/patient Messages/requests SHARE Healthgrid Certification EHR SSA STEPVH CA Semantic Health Interoperability RIDE Interoperability TMA Bridge Interop. approach INFOBIOMED BIOPATTERN SEMANTIC MINING Long time research Implementation Short time research NEC 2005

  28. More information • References • http://lyon2003.healthgrid.org/program.php • http://clermont2004.healthgrid.org/program.php • http://oxford2005. healthgrid.org/program.php • HG2004, HG2005 Proceedings • ‘White paper’ • http://www.healthgrid.org/download.php (June 2004) • SHARE Project – Road Maps NEC 2005

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