The 2 Seas Trade Project (2ST) Steve Samson Trade Development Manager Kent County Council

1. The 2 Seas Trade Project (2ST) Steve Samson Trade Development Manager Kent County Council steve.samson@kent.gov.uk

2. Project Partners www.2seastrade.eu

3. Project Objectives • To establish a cross-border trade support network • To help SMEs to do business in another 2ST partner area • To promote the 2 Seas Trade area as a place to do business www.2seastrade.eu

4. Project Activities & Outputs

5. Communication www.2seastrade.eu

6. Who has benefited? www.2seastrade.eu

7. Cross-Border Added Value • A genuine cross-border issue • Trade cannot be achieved in isolation • Partner expertise & networks • Joint planning & delivery www.2seastrade.eu

8. Sustainability & Lasting Impact • Web-based resources available to businesses • Case studies & success stories • Great network of partners (future SME referrals) • Referrals to wider support services www.2seastrade.eu

9. Lessons Learnt & Next Steps • Interreg Projects are complex • Different levels of expertise • Clarity • Flexibility • Planning, planning, planning! What next? • 14 months of project delivery • Future project? www.2seastrade.eu

10. A Lesson in International Marketing www.2seastrade.eu

12. Aim TIME should enable companies and technology providers to meet in order to: • develop skills and knowledge about challenges in 3 maritime sectors • enhance productivity thanks to innovation • identify cross border or national business opportunities

13. Objectives Doing so the TIME project has the objective to: • increase the competitiveness of the companies in the supply chain of 3 maritime sectors • help companies, not linked with maritime activities, to use their technologies in order to become suppliers of maritime activities • encourage maritime companies to use new technologies to create competitive advantages • help SME’s to expand into international maritime markets • define methodologies and tools to facilitate the cross border collaborations for technology transfer or to find new markets • strengthen the development of the maritime economy of the three participating regions.

14. Methodolody – desk research Preliminary desk research of 6 maritime sectors • Logistics • Sport / leisure and coastal tourism • Fishing / Aquaculture • Marine Renewable Energy • Shipping • Security Selected activity sectors for TIME • Security & Logistics • Maritime Renewable energy • Fishing/Aquaculture

15. Methodology – broad mapping survey 2 broad mapping approaches • face to face interviews • a supply chain mapping methodology identification of specific problems and opportunities in the 3 sectors For more details see downloadable document: Final Report www.time2seas.eu

16. Methodology – matching process • intensified company visits • ad hoc bilateral meetings • collaborative workshops • professional events for each sector • set up relations via professional clubs for each sector

17. Results on matching and cross border collaboration • 234 companies visited • 43 technology providers visited • 50 collaboration meetings organized • 20 collaborations initiated – both national and cross border • 8 cross boarder collaboration agreements

18. Results on communication and dissemination Communication – professional events • Serious gaming technology and use of access and video control systems in Security & Logistics (27 persons attended) – 26/05/11 – Ostend (B) • How reducing cost of logistics of off shore wind energy farms during construction and maintenance through optimisation? (31 persons attended) • Fishing for the good ideas from our fisheries! (30 persons attended) – 19/10/12 – Wimille (F) Dissemination – professional club meetings • Contact less technologies in port security and logistics – Ghent – July 5th 2012 • Security & Logistics and Serious Gaming – Calais – July 11th 2012 • Renewable Energy Professional club meeting – Wimille – October 18th 2012 • Club Fishing sector – Calais – November 29th 2012

19. Lessons learned Companies/Technology providers Difficulties • CEO’s open mindedness to cross border cooperation • Organisations rigidity to its own procedures and rules. • Companies’ business strategy and availability. • Business creation is time consuming an depends on the matching of the right people. Benefits • Crossing of different technologies, industries and sectors to generate innovation: • Contact less technologies vs. ports logistics • Contact less technologies vs. fishing industry • Game industry vs. ports security • Eye opener for companies and organizations not familiar with cross border projects • TIME delivered different positive side effects: • Expansion on Flanders for professional organizations such as CITC EURA RFID (FR) and Game Industry North (FR) • TIME allowed some organizations to acknowledge some similar activities which were taking place across the border

20. Lessons learned Project partners Difficulties • Keeping the same partners / staff on the whole duration of the project • Collaboration with the communication agency Benefits • Frequent interactions between the project partners accelerate the acquisition of knowledge and know-how. • Complementary Interreg projects should cooperate to create synergies

21. Future approaches - opportunities Companies / Technology providers • Specific supplier gaps and innovation potentials could be tackled. • Creation of innovation minded companies and technology resource centers databases. • Creation of a qualitative evidence base for justifying future collaborations between companies or technology providers • Build further on organizational relationships started in the project Use Rampion meet-the-buyer and other events for further develop relationships Project Partners • Sharing of culture on SMEs innovation support between the project partners and the regions in general • Input to regional innovation strategies and Common Strategic Framework for future structural funds • Opportunities for inter- cluster partnering: f.e. MSE and Flanders Marine Cluster • Stimulate ideas on regional ‘smart’ specialization

22. IDEA : Improving Drugs Efficacy and Availability F. AFFOUARD University Lille 1 - Frederic.affouard@univ-lille1.fr http://idea.univ-lille1.fr

23. Motivations • The vast majority (80%) of drugs shows prepared as solid products(powders, tablets , capsules) • These solids exist in different forms (crystals & amorphous) which behave differently in the human body • Strong impact on therapeutic efficacy, safety and and product stability

24. ‘2 seas’ opportunity IDEA project • Major bottleneck: 80% of drugs show poor water solubility • Current awareness in industry for research and training reorientation so as to incorporate understanding of the solid state of drugs • Presence in the 2-seas EU region of recognized researchers in the challenging field of solid state pharmaceutical science: in physics, chemistry and pharmacy

25. IDEA Partners FRANCE • University Lille1 (M. Descamps / F. Affouard) • University Lille2 (J. Siepmann) BELGIUM • University of Ghent(C. Vervaet) • SME SEPS Pharma in Ghent (Y. Gonissen) UK • University of Cambridge (W. Jones) • University of East Anglia (D. Craig / S. Qi)

26. Activity 1 • Trans-disciplinary technological platform (physics, chemistry, pharmacy) • dedicated to: • Material synthesis • Advanced characterisation • Formulation of pharmaceutical materials

27. Mutualised rich and complementary know-how and equipments bases • Preparation: solvent evaporation and freeze-drying (Cambridge, Lille2), hot-melt extrusion and spray-drying (Ghent, Lille2, Norfolk), co-grinding (Cambridge, Lille1) • Characterization: Raman, Infra-red and terahertz and relaxational spectroscopies( Cambridge, Lille1), thermal analysis and X-ray diffraction (Cambridge, Norwich, Lille1), drug dissolution and particle size analysis (Lille2, Ghent), Electron Microscopy (Cambridge, Lille1, Ghent), Molecular modelling (Cambridge, Lille1) • Formulation: tablets, implants, micro- and nano-particles (Lille2, Ghent, Norwich).

28. Activity 2 • Research activity programme with technical applications to the design of new solid state pharmaceuticals • Facilitate the development of both new and existing drugs with improved properties • Use of nanoparticle technologies, amorphous forms and molecular complexations • Fast and efficient validation provided by the SME SEPS-PHARMA

29. How to increase drug solubility ? • Transform the drug into the amorphous state (disordered) • Stabilize the amorphous drugs using polymeric matrices EXTRUSION MILLING

30. IDEA partnership: • Optimized protocoles & best Drugs/Polymers • Upscaled at the SME SEPS PHARM site • Prototypes of drug products • Communications: • Leading scientific journals • International conferences • Workshops and seminars to industries & academics

31. Activity 3 • Training centre for a new trade dedicated to the optimization of the solid-state drug manufacturing processes • Training provided by the members of the partnership • Meet the need of pharmaceutical firms • Targets: students and personnel from industries undertaking continuing professional development

32. Training centre • Students formed on this project so far: • 2 PhD students & 2 postdoc (Lille1) • 3 PhD & 2 master students (Cambridge) • 5 PhD & 3 master students (Lille 2) • 2 PhD & 1 Erasmus student (Ghent) • 2 PhD students & 1 postdoc (East Anglia) • 1 PhD & 1 Master student (SEPS Pharma) • “Training Days” at partner sites(Lille, Ghent, Cambridge, Norwich) • Lectures and MASTER courses • Training seminars at industries sites

33. Conclusion & perspective • IDEA partnership (Lille, Ghent, Cambridge, Norwich): Research activity + Training centre + technological platform • Training : • University Ghent & Lille (1+2): Joint Master “solid state pharmaceutical science” • ERASMUS Mundus proposal • Marie-Curie (Network, Industrial Doctorates) • Strengthening of the links with industries • Cluster initiative??? INTERREG 5 ???