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Healthy Mind, Healthy Sight.

Healthy Mind, Healthy Sight. Healthy Mind, Healthy Sight. Dr . Guy Eakin, BrightFocus Foundation Dr . Elia Duh, Johns Hopkins University Dr. Seth Margolis, Johns Hopkins University. BrightFocus Foundation. A Non-Profit Organization Based in Clarksburg, Maryland

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Healthy Mind, Healthy Sight.

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  1. Healthy Mind, Healthy Sight.

  2. Healthy Mind, Healthy Sight. • Dr. Guy Eakin, BrightFocus Foundation • Dr. Elia Duh, Johns Hopkins University • Dr. Seth Margolis, Johns Hopkins University

  3. BrightFocus Foundation • A Non-Profit Organization • Based in Clarksburg, Maryland • Supporting Research and Education to Save Mind and Sight

  4. The Need for Cures is Great One in 16 Americans, age 40 and above, has Alzheimer’s disease, macular degeneration, or glaucoma.

  5. Our Research Mission Support Innovative, Cutting-Edge Research • BrightFocus has awarded more than 1,000 grants totaling $130 million. More than $26 million awarded in last four years.

  6. Public Education Providing the Public with Information: • Risk Factors • Early Detection /Diagnosis • Current Treatments • Coping Strategies for Patients and Caregivers

  7. Glaucoma and Age-Related Macular Degeneration Elia Duh, M.D. Wilmer Eye Institute Johns Hopkins School of Medicine October 30, 2013

  8. Glaucoma and Age-related Macular Degeneration (AMD) • Two of the most common causes of blindness in the United States • Risk factors: • AGE: especially over the age of 60 • Family history • Race

  9. Glaucoma • Glaucoma: • Fluid builds up in the eye, so that the eye pressure rises • This higher eye pressure can damage the optic nerve over time

  10. Glaucoma • Symptoms • Treatment • Research to improve treatments

  11. Age-Related Macular Degeneration (AMD) • AMD: • Eye condition among people age 50 or older • It gradually damages (and even destroys) the macula • Dry form of AMD • Wet form of AMD

  12. Age-Related Macular Degeneration (AMD) • Symptoms • Treatments • Research to improve treatments for AMD

  13. Alzheimer’s Disease Dr. Seth MargolisJohns Hopkins UniversityDepartment of Biological Chemistry Johns Hopkins School of Medicine October 30, 2013

  14. Behavior Circuits Neurons Synapses Molecules

  15. Abnormal Memory Amyloid Neuron Injury Mild Dementia Normal Inflammatory Cell damage Genetic mutation and Risk factors Misfolding and aggregation of Ab and tau followed by plaques and tangles Cell death Clinical diagnosis 0 20 40 (Years) 60 80 100 Preventative Modifying Symptomatic

  16. Daniel Colon-Ramos Karl Deisseroth

  17. Spine Abnormalities are a Hallmark of Cognitive Disorders Unaffected Affected Non-syndromic MR Down’s Syndrome Rett Syndrome Fragile X syndrome Phenylketonuria Angelman Syndrome Alzheimer’s disease Reviewed in Ramakerset al. 2002, TINS

  18. Dendritic Spine Density Changes with Development Spine density WenbiaoGan Age

  19. Embryonic Braak 3 3 4 5 5 6 86 82 93 102 89 88 anti-N-E5 anti-EphB2

  20. Genetic Cross Between Alzheimer Mice Models and Ephexin5 Knockout Mice Female Male X Alzheimer Mice Ephexin5-/Ephexin5- Alzheimer’s Ephexin5-/Ephexin5+ Electrophysiological properties: Dendritic spine morphology: Learning and memory:

  21. If You Have Questions… • Visit our website:www.BrightFocus.org • Send us an email:info@BrightFocus.org • Give us a call:1-800-437-2423

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