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Pulmonary Oxygen Toxicity. Oxygen is probably the most important single factorMost other factors act by increasing need for supplemental oxygen or by alterating the sensitivity to oxygenEffects are mediated by reactive oxygen speciesdirect effectsinflammatory cascadesstimulation of growth facto
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1. Oxygen Toxicity and ROP J Baier MD
2. Pulmonary Oxygen Toxicity Oxygen is probably the most important single factor
Most other factors act by increasing need for supplemental oxygen or by alterating the sensitivity to oxygen
Effects are mediated by reactive oxygen species
direct effects
inflammatory cascades
stimulation of growth factors
3. Reactive Oxygen Species Superoxide O2- Hydrogen Peroxide H2O2 Singlet Oxygen O. Lipid Peroxide RCOO. Hydroxyl radical HO.