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Moving phase boundaries in DNA and coiled-coils control mechanical response

Moving phase boundaries in DNA and coiled-coils control mechanical response Ritwik Raj and Prashant K. Purohit , NSEC DMR 0832802. Energy. unfolded. folded. Stretch.

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Moving phase boundaries in DNA and coiled-coils control mechanical response

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  1. Moving phase boundaries in DNA and coiled-coils control mechanical response Ritwik Raj and Prashant K. Purohit, NSEC DMR 0832802 Energy unfolded folded Stretch We use a 1D continuum model with a multi-well free energy to study the sequentialunfolding of coiled-coil proteins and DNA characterized by force plateaus in theirforce-stretch response. Coiled-coil proteins such as vimentin, desmin, lamin, etc., formintermediate filaments, which in turn, form cytoskeletal andmatrix networks. Diseases, such as, muscular dystrophy arecaused by deficient mechanical response of desmin. Myosin response Theory Experiment We have shown that force-plateaus in the mechanical response are caused bymoving interfaces between the folded and unfolded regions of the coiled-coil protein. Raj and Purohit, submitted to EPL, (2010).

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