1 / 3

DNA Damage Response

Phenotype. Targeted. DNA Damage Response. Tissues. Mutation. Survival. Intercellular Signaling. Non-Targeted. Targeted vs Non-Targeted Radiation Effects. Targeted effects are proportional to radiation dose, e.g. cell kill

amaya-hartman
Download Presentation

DNA Damage Response

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Phenotype Targeted DNA Damage Response Tissues Mutation Survival Intercellular Signaling Non-Targeted

  2. Targeted vs Non-Targeted Radiation Effects • Targeted effects are proportional to radiation dose, e.g. cell kill • The dose dependence of non-targeted effects are more like switches rather than rheostats • Both contribute to cancer risk

  3. What is the Utility of Incorporating NTE into Risk Paradigms? • NTE are the mechanistic basis of non-cancer health effects • Necessary for the biological veracity of LNT at low dose/dose rate where epidemiological data are uncertain • May identify susceptible populations • Could provide avenues for protection after radiation exposure

More Related