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Some aspects of our projects with Quebec-populations

Some aspects of our projects with Quebec-populations. Lucas Michel1 , Blanchet C . 1 , Holub B . J. 2 , Dewailly É . 1. 1. Public Health Research Unit of Laval University Medical Researc h Center - CHUQ,Canada

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Some aspects of our projects with Quebec-populations

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  1. Some aspects of our projectswith Quebec-populations Lucas Michel1, Blanchet C.1, Holub B. J.2, Dewailly É.1 1. Public Health Research Unitof Laval University Medical Research Center-CHUQ,Canada 2. Department of Human Biology and Nutritional Sciences, University ofGuelph,Canada michel.lucas@crchul.ulaval.ca UNIVERSITÉ LAVAL International Scientific Conference on seal oil Ottawa, June 7, 2004

  2. Santé Québec 1990-92

  3. All surveys followed a common standard protocol Face-to-face interviews & clinical sessions - Information on physical, social & psychosocial health Plasma PLs FA concentrations (1992-1996) - Capillary GLC at Guelph University (B.J. Holub) N=2803 (1323 M & 1480 W), 18-74 yrs of age - 52% Quebecers (n=1460, mean age= 40.1 yr) - 33% Cree (n=917, mean age=35.2 yr) - 15% Inuit (n=426, mean age=38.2 yr)

  4. Characteristics of subjects who participated in the Santé Québec Health Surveysa,b

  5. Marine Food Intake (from 24-h dietary recalls) P for trend = 0.0002 Marine Food Intake (g/d) Dewailly et al. Lipids. 2003 Apr;38(4):359-65.

  6. Marine Food Intake (from 24-h dietary recalls) P for trend = 0.0002 Marine Food Intake (g/d) 170 mg EPA+DHA 2115 mg EPA+DHA 700-900 mg EPA+DHA Dewailly et al. Lipids. 2003 Apr;38(4):359-65.

  7. Values with same superscripts are not significantly different (p ≥ 0.05)

  8. Threshold value for a beneficial effect 0.3% Quebecer 31% Cree 84% Inuit TABLE 3 Regression coefficients ( values)1 of EPA+DHA in relation with HDL cholesterol and triacylglycerols as dependant variables. P for trend = 0.0002 1 Obtained from multiple linear regression analysis; one model for each CVD risk factor; each model included age, sex, body mass index, waist girth, smoking, alcohol intake Dewailly et al. Lipids. 2003 Apr;38(4):359-65.

  9. HDL cholesterol according quintile of EPA+DHA Inuit of Nunavik P for trend = 0.0002 Dewailly et al. Am J Clin Nutr. 2001 Oct;74(4):464-73.

  10. Triacylglycerols according to quintile of EPA+DHA Inuit of Nunavik P for trend = 0.03 Dewailly et al. Am J Clin Nutr. 2001 Oct;74(4):464-73.

  11. OR for HDL-Chol 0.9 mmol/L Quebecers P for trend = 0.03 FIG 1. Odds ratios (95% CIs) of prevalent high-risk concentration of plasma HDL-Chol by quintiles of plasma PLs ratio of EPA/AA. Dewailly et al. Am J Clin Nutr. 2001 Nov;74(5):603-11.

  12. Four Types of Dietary EFA that predict the % of Highly Unsaturated Fatty Acids (HUFA) in tissues- a useful surrogate clinical marker 18:2 n-6 18:3 n-3 HUFA n-6 (20:3, 20:4, 22:4. 22:5n-6) HUFA n-3 (20:3, 20:4, 20:5, 22:5, 22:6n-3) Total HUFA Lands, Am J Clin Nutr 1995; 61(suppl): 721S-25S.

  13. Values with same superscripts are not significantly different (p ≥ 0.05)

  14. Values with same superscripts are not significantly different (p ≥ 0.05)

  15. Values with same superscripts are not significantly different (p ≥ 0.05)

  16. Variability of HUFA in tissues n-6 HUFA n-3 HUFA 50-74 y 35-49 y 18-34 y a a a Quebecer Cree Inuit

  17. FIG. 2: Coronary heart disease (CHD) mortality rates (for 100,000) associated with tissue HUFA proportions. Lands W.E.M. Lipids 2003 : 317-21. Lands et al. 1992. BBA. (1180):147-162. Lands et al. 1992. FASEB J.( 6):2530-2536. Dewailly E. et al. 2002. Am J Clin Nutr. 76(1):85-92. Dewailly E. et al. 2002. Am J Clin Nutr. 76(1):85-92.   Dewailly E et al. 2001. Am J Clin Nutr 74(5):603-11.

  18. Contribution of Traditional Foods to EPA+DHA intake among the Inuit of Nunavik

  19. 70.8-75.5 g/d 37.1-42.7 g/d 6.9-9.9 g/d 8.6-11.1 g/d 12.4-13.4 g/d 5.7-8.4 g/d Fat (Misirak): 1.6 g/d 10.4-13.3 g/d Fat (Misirak): 1.5 g/d

  20. EPA+DHA AHA 2002 ISSFAL 1999 0.5–1.8 g/day 0.7 g/day CONCLUSION • EPA+DHA plasma PLs • 2 times greater than Cree • 4 times greater than Quebeces Sign. Diff. in CVD risk factor levels among the 3 pop HDL-chol, Total/HDL-chol, TG, SBP & DBP, Insuline - lowest among Inuit despite higher cig. Smoking & obesity Fish intake among Inuit - 2 times greater than Cree - 10 times greater than Quebecer

  21. CONCLUSION • EPA+DHA plasma PLs • 2 times greater than Cree • 4 times greater than Quebeces Sign. Diff. in CVD risk factor levels among the 3 pop HDL-chol, Total/HDL-chol, TG, SBP & DBP, Insuline - lowest among Inuit despite higher cig. Smoking & obesity Fish intake among Inuit - 2 times greater than Cree - 10 times greater than Quebecer Greater availability of market food in many Aboriginal regions appears to be more attracting for young people.

  22. The Inuit Diet and Health Study An International Study of the Impact of Diet on Health and Disease among the Inuit and Yupik

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