1 / 6

Laboratory Procedures and Standards Subcommittee

Laboratory Procedures and Standards Subcommittee. January 26, 2012. Second Screen study. Stuart Shapira from CDC presented the preliminary data from the retrospective study Higher incidence of CH in 2 screen states Gender difference – 2:1 female to male incidence for CH

miette
Download Presentation

Laboratory Procedures and Standards Subcommittee

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Laboratory Procedures and Standards Subcommittee January 26, 2012

  2. Second Screen study • Stuart Shapira from CDC presented the preliminary data from the retrospective study • Higher incidence of CH in 2 screen states • Gender difference – 2:1 female to male incidence for CH • Birth weight / feeding method difference in CH incidence

  3. Second Screen study • CAH • Reported incidence of CAH in 2 screen states is higher • Nonclassical in particular • Salt wasting- about 2x as many cases picked up in 2 screen states • Gender not different, but significant difference by birth weight-more picked up in normal birth weight range in 2 screen states • No difference in types of cases picked up on first screen between groups • Second screen did pick up more simple virilizers and nonclassics • Higher proportion of Hispanics picked up on second scree

  4. Second Screen Study • Still cleaning data • Going to do some modeling for the cases • Going to evaluate the clinical significance of those detected on the second screen • Limits due to lack of long term follow-up, screening algorithms and retrospective analysis with missing data • Will follow-up in subcommittee at May meeting

  5. NLM standing items • CF LOINC mutation reporting • Working to standardize the lists and order • Have 116 LOINC codes developed • cDNA, protein or traditional name searchable • Reports will need to be very clear for reporting purposes in order to not be confusing in the report given wide variety in reporting terminology and methodology

  6. NLM standing item • Hemoglobinopathy reporting • New code for conditions suspected • Will accommodate for those that confirm diagnosis as well as suspected diagnoses • Using CLSI guidelines to develop results reporting terminology • Reason for lab test- to include mandatory second screen.

More Related