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THP-1 24h

Supplementary Figure 1. A. C. ATO. Ctl ATO NAC NAC 1.5 3 mM. Nrf-2. HO-1. C. NQO-1. HSP90. Nrf-2. N. TBP. ATO. HL60. B. HL60 24h. β-actin. THP-1 24h. HO-1. NQO-1.

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THP-1 24h

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  1. Supplementary Figure 1 A C ATO Ctl ATO NAC NAC 1.5 3 mM Nrf-2 HO-1 C NQO-1 HSP90 Nrf-2 N TBP ATO HL60 B HL60 24h β-actin THP-1 24h HO-1 NQO-1 ATO 6.25 µM - + + + + + + + NAC 1.5 mM - - + - - - - - NAC 3 mM - - - + - - - - Tiron 1.5 mM - - - - + - - - Tiron 3 mM - - - - - + - - Mannitol 2.5 mM - - - - - - + - Mannitol 5 mM - - - - - - - + ATO 6.25 µM - + + + + + + + NAC 3 mM - - + - - - - - NAC 6 mM - - - + - - - - Tiron 1.5 mM - - - - + - - - Tiron 3 mM - - - - - + - - Mannitol 2.5 mM - - - - - - + - Mannitol 5 mM - - - - - - - + β-actin HO-1 NQO-1

  2. Supplementary Figure 2 K562 HL60 - + - + tBHQ HO-1 β-actin K562 cells Viability (%) ATO (µM)

  3. Supplementary Figure 3 - ZnPP +ZnPP HL60, 24h DEVDase Units Methotrex 10 µM Ara-C 5 µM Daunorub 0.1 µM Control

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