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Wake Up and Smell the Caffeine

Wake Up and Smell the Caffeine. Psychology 2800. Introduction. The most popular psychoactive drug in North America How many people here DO NOT ingest caffeine?. Introduction. That includes: Coffee 130 mg Tea 40 mg Soft Drinks (colas) 30 – 90 mg Cold and Headache medications 15 – 50 mg

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Wake Up and Smell the Caffeine

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  1. Wake Up and Smell the Caffeine Psychology 2800 Caffeine

  2. Introduction • The most popular psychoactive drug in North America • How many people here DO NOT ingest caffeine? Caffeine

  3. Caffeine

  4. Introduction • That includes: • Coffee 130 mg • Tea 40 mg • Soft Drinks (colas) 30 – 90 mg • Cold and Headache medications 15 – 50 mg • Rev ?, probably about 100 mg • Chocolate! 50 – 100 mg • Wake up pills 100 – 500 mg Caffeine

  5. Introduction • Almost always taken orally, absorbed in small intestine. • Crosses all barriers • Absorbed more slowly from cold beverages • Less than 2% is excreted Caffeine

  6. Metabolism • Half life is between 30 min and 3.5 hr • Metabolism slowed by birth control pills • Sped up by broccoli! • 2x faster in smokers Caffeine

  7. Metabolism • That was with adults (well not kids anyway) • Different deal in kids and infants • 85% excreted • 4 DAY half life • Different pathways and metabolism than in adults • More similar to non-humans Caffeine

  8. Neurophysiological Effects. • Like alcohol, we don’t know! • Might block adenosine • Neuromodulator that inhibits firing • So, caffeine disinhibits? • High doeses block benzodiazipine receptors Caffeine

  9. Neurophysiological Effects • Might cause release of epinephrine • Causes smooth muscles to relax, striate muscles to contract • Decreases airway resistance • Good for asthma, colds • Constriction of blood vessels to the brain • Dilation other places Caffeine

  10. Neuropshysiological Effects • Not sure if it helps performance • Does reduce drowsiness,boredom. • Increases FA levels, could be performance enhancing, especially for long athletic events. • Controlled substance. • Increases time in light sleep • Stages 1 and 2 • Can counteract barbiturates. Caffeine

  11. Effects on Nonhumans • Small doses increase SMA • Large doses do the opposite • Increases FR responding • Affects timing • Increases suppressed behaviour. • Generalizes to coke, not to amphetamine. Caffeine

  12. But, how does that first cup make you feel? • Humans are great at discriminating • 1.8 mg, about a sip of coffee!! • Caffeine makes us: • Energized • Focused • Motivated • Same in non users • All at low-moderate doses (20-200 mg) • About a cup of coffee. Caffeine

  13. Could I ever use a coffee • Tolerance • Sustained use leads to more adenosine receptors • Whole deal changes if big dose given to non users. • Withdrawal • Headache • Flu like symptoms • Bad attitude in general • 100 mg a day, most all of us! Caffeine

  14. Reinforcing Properties • Hard to get animals to self-administer • Will prime cocaine use • Lots of variation in us • Task demands • Caffeine experience. • Demand is relatively inelastic. • Late 1970s, 6 bucks a pound. Caffeine

  15. Bad Stuff • Cancer? • Caffeinism • OD? • 30-80 cups of coffee • Reproduction • Chromosomal damage? • Toxicity • Cardiac effects? • Depends on method Caffeine

  16. Beware the International Coffee Conspiracy! Caffeine

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