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Characterization of delivery systems for nanomedicine Dr. John A. Dagata

Characterization of delivery systems for nanomedicine Dr. John A. Dagata. source: NCI CNPlan. Benefits and advantages of nanomedicine:. Targeted nanoparticle delivery systems One of the most promising nanomedicine platforms

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Characterization of delivery systems for nanomedicine Dr. John A. Dagata

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  1. Characterization of delivery systems for nanomedicine Dr. John A. Dagata

  2. source: NCI CNPlan Benefits and advantages of nanomedicine: • Targeted nanoparticle delivery systems • One of the most promising nanomedicine platforms • Use an engineered virus-like particle to direct therapeutics & diagnostics only to cancer cells • Lower dosage • Reduced costs & side effects

  3. NIST-NCI-FDA Alliance: • Impact of healthcare costs on the US economy • Protocols and standards for faster move into clinical trials • CNPlan (NCI 2004) • Critical Path Initiative (FDA 2004) Technology: Methodologies for nonspecific adhesion of bio-nanoparticles to surfaces for high-magnification imaging and characterization

  4. Commercial Applications: • Drug discovery and development • Quality assurance (manufacturability and potency) • Environmental health & safety

  5. Drug discovery and development (collaboration with Esther Chang, Georgetown University Medical Center)

  6. 500 nm • Metrology of soft material: • Small sample volume (10 L) • Adjustment of solution properties (essential for actual drug formulations) • Fluid scanning probe microscopy of intact liposomes • Non-optical statistical size distribution and zeta potential SPM tip tip probing liposome tip probing SPIO SPIO NDS

  7. Collaboration Opportunities: CRADA SBIR For technical details see the posters: Physical characterization of liposome-based targeted nanoparticle delivery systems with encapsulated MRI contrast agents Imaging, characterization, and manipulation of nanobioparticles: Fluid scanning probe and surface zeta potential measurements of targeted delivery systems N. Farkas, et al.

  8. Contact Information: John A. Dagata Precision Engineering Division Manufacturing Engineering Laboratory National Institute of Standards & Technology 100 Bureau Drive MS 8212 Gaithersburg MD 20899-8212 301-975-3597 tel. 301-869-0822 fax john.dagata@nist.gov

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