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SOMATOSENSORY PHYSIOLOGY (PAIN AND TEMPERATURE)

SOMATOSENSORY PHYSIOLOGY (PAIN AND TEMPERATURE). Pain and Temperature. Pathways Classes of nociceptors Fast and slow pain Pain transmission neurons Gate control theory of pain. Pain and Temperature. Descending inhibitory pathways Peripheral mechanisms Neuropathic pain Referred pain

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SOMATOSENSORY PHYSIOLOGY (PAIN AND TEMPERATURE)

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  1. SOMATOSENSORY PHYSIOLOGY(PAIN AND TEMPERATURE)

  2. Pain and Temperature • Pathways • Classes of nociceptors • Fast and slow pain • Pain transmission neurons • Gate control theory of pain

  3. Pain and Temperature • Descending inhibitory pathways • Peripheral mechanisms • Neuropathic pain • Referred pain • Thermoreceptors

  4. Anterolateral and Dorsal Column Systems From Kandel,Schwartz, and Jessell, 2000, 22-14

  5. From Kandel,Schwartz, and Jessell, 2000, 24-8

  6. Pain • Unpleasant sensation or experience • Subjective and individualized • Moods and circumstances • Pain and nociceptors

  7. Classes of Nociceptors • Thermal nociceptors • Mechanical nociceptors • Polymodal nociceptors

  8. Qualities of Fast and Slow Pain

  9. Pain Transmission Neurons

  10. Gate Control Theory of Pain

  11. Descending Inhibitory Pathways

  12. Spinal Cord Integration of Nociceptor Afferents and Descending Pathways From Kandel,Schwartz, and Jessell, 2000, 24-13

  13. Opiates • Receptors • (gut, respiratory system, descending pathways) • Opiate peptides (morphine, codine) • Endogenous opiate peptides • Enkephalins – descending pathways • Dynorphins – descending pathways • -endorphins – hypothalamus

  14. Peripheral Mechanisms From Kandel,Schwartz, and Jessell, 2000, 24-7

  15. Agents That Activate or Sensitize Nociceptors * Calcitonin gene-related protein (CGRP)

  16. Hyperalgesia

  17. Neuropathic Pain • Phantom Pain • Associated with amputations • Entrapment Lesions • Nerve irritation or inflammation • Thalamic Pain Syndrome • Vascular lesions involving thalamus (VPL) • Patients describe this pain as most excruciating pain ever experienced

  18. Referred Pain From Kandel,Schwartz, and Jessell, 2000, 24-3

  19. Thermoreceptors

  20. Temperature Sensitive Fibers From Byrne and Levy 1998

  21. From Kandel,Schwartz, and Jessell, 2000, 22-9

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