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2D-NMR

2D-NMR. COSY , CO rrellation S pectroscop Y. COSY. http://www.chem.queensu.ca/FACILITIES/ NMR/nmr/chem806/Web/homo2_files/frame.htm. COSY, CO rrellation S pectroscop Y. 2D-NMR: COSY. C 5 H 10 O 2 IR: 1730 and 1200 cm -1 , no peaks above 3000 cm -1. COSY: C 5 H 10 O 2.

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2D-NMR

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  1. 2D-NMR

  2. COSY, COrrellation SpectroscopY

  3. COSY http://www.chem.queensu.ca/FACILITIES/ NMR/nmr/chem806/Web/homo2_files/frame.htm

  4. COSY, COrrellation SpectroscopY

  5. 2D-NMR: COSY C5H10O2 IR: 1730 and 1200 cm-1, no peaks above 3000 cm-1

  6. COSY:C5H10O2

  7. C6H12O2 IR: 1730 and 1200 cm-1, no peaks above 3000 cm-1 2D-NMR: COSY

  8. 2D-NMR: COSY

  9. 2 1 2D-NMR: COSY 1H 2H 3H 3H C4H9Cl

  10. 2D-NMR: COSY C14H20O2 (ester)

  11. 2D-NMR: COSY C14H20O2

  12. Given the COSY on the next page, assign all protons and calculate coupling constants, J23, J24 and J34? (Because of the heterocyclic ring, H-2 has the highest chemical shift and the ortho coupling constant J2-3 ~ 4Hz, significantly smaller than a normal ortho coupling constant. 2D-NMR: COSY

  13. 2D-NMR: COSY

  14. Problem - Identify where the methyl is located on the quinoline Ring and assign all protons. Show correlation lines on the COSY spectrum to support your assignments. 2D-NMR: COSY

  15. 2D-NMR 1H-13C Correllation Spectroscopy (HETCOR, HMQC, HSQC)

  16. 2D-NMR 1H-13C Correllation Spectroscopy (HETCOR, HMQC, HSQC) C5H10O

  17. C4H9I

  18. COSY C4H9I HMQC

  19. Unknown: C10H12O

  20. Unknown: C10H12O

  21. Unknown: C10H12O

  22. Unknown: C10H12O

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