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Processed Amniotic Membrane Allografts

Processed Amniotic Membrane Allografts. Amniotic Membrane Allografts. A unique, avascular membrane separating the mother from the fetus. Provides an incubating environment promoting cellular differentiation. Provides an immunological barrier to prevent “foreign body” rejection.

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Processed Amniotic Membrane Allografts

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  1. Processed Amniotic Membrane Allografts

  2. Amniotic Membrane Allografts

  3. A unique, avascular membrane separating the mother from the fetus. Provides an incubating environment promoting cellular differentiation. Provides an immunological barrier to prevent “foreign body” rejection. What Is Human Amniotic Membrane?

  4. Anatomical Profile: AM

  5. Anatomy of the Ocular Surface (1) Conjunctival Epithelium (2) Corneal Epithelium (6) Limbus – Stem Cells

  6. De Rotth. conjunctival defects (1940). Lavery. lime burn of conjunctiva and cornea (1946). Sorsbyet al. caustic soda burns (1947). ALLOTRANSPLANTAT [late 80’s USSR->Venezuela, DR] Batlle and Perdomo. Conjunctival substitute with placental allotransplant. Scientific Poster 25. American Academy of Ophthalmology meeting. Chicago, IL USA. October 1993. Kim and Tseng. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 14:473-84, 1995. [ History of AM in Ophthalmology

  7. Surgical Indications: AM • Pterygium Excision • Corneal Ulcerations/Perforations • Chemical/Thermal Burns • Bullous Keratopathy • Ocular Dermoids/Tumors • Fornix Reconstruction/Symblepharon • Stem Cell Transplants

  8. Pterygium • A mutated growth on the surface of the eye • Requires surgical excision and placement of graft

  9. Corneal Ulcerations/perforations • A break or defect in corneal epithelium • Often secondary to other systemic diseases.

  10. Chemical/thermal Burns • Chemical burns often caused by alkali • Potentially devastating trauma to surface of the eye • Limbal graft possibly indicated

  11. Bullous Keratopathy • Edema of the corneal endothelium • Very common and usually affects individuals over 50 years of age.

  12. Dermoid/tumor Removal • Benign congenital tumors containing foreign tissue • Commonly found at the limbus

  13. Fornix Reconstruction • Fibrous tract that connects bulbar conj to conj of eyelid • Secondary to other acquired or traumatic conditions • Required reconstruction of ocular surface and eyelids

  14. Surgical Techniques: Amt/pterygium

  15. Tested & Safe Dehydrated Terminally Sterilized Strict, quality-controlled protocols Device-like quality Ambiodry2 Overview

  16. AmbioDry: Safe & Viable Intact epithelial cell layer Intact dense connective, basement membrane Presence of loose fibroblast network

  17. AmbioDry: Logistical Features • Storage: Room-temp • No freezer required • No dry ice shipments • Simple prep: No soaks or rinses • IOP Customer Service: 24 Hrs/7 Days

  18. AmbioDry: Surgical Advantages • Substrate-free • Dry-state handling & trimming • Visual orientation identification • No tears or buttonholes • Device-like tissue quality

  19. AmbioDry Configurations • 1 x 2 cm • 2 x 3 cm • 4 x 4 cm

  20. Reimbursement Codes Supply code: V2790 CPT code: 65780 ocular surface reconstruction; Amniotic membrane transplantation

  21. The sutureless approach to eye surgery. Fibrin (biological) adhesive Eliminates sutures Reduces surgical time Improved patient care Better healing AmbioDry & Tisseel

  22. AmbioDry & Tisseel Video

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