Orientation

1. Orientation Biomedical Informatics Graduate Program Presented by: Bill Hersh, Joanne Valerius Shannon McWeeney Date: September 26, 2014

2. Overview of Today’s Activities • Welcome and Introductions • Overview of Program and Tracks • Student Pictures • Staff Introductions • Professional Conduct • Lunch • Campus Tours

3. Department of Medical Informatics &Clinical Epidemiology (DMICE) • One of 26 departments in OHSU School of Medicine • Mission is to provide leadership, discovery, and dissemination of knowledge in the areas of biomedical informatics and clinical epidemiology • Fulfilled through programs of research, education, and service • Department leadership • William Hersh, MD - Chair • Cynthia Morris, PhD - Vice Chair for Education and Training • Joan Ash, PhD - Vice Chair for Faculty Development • Shannon McWeeney, PhD, Head, Division of Bioinformatics & Computational Biology • David Dorr, MD, MS - Vice Chair for Clinical Informatics • Heidi Nelson, MD, MPH - Vice Chair for Clinical Epidemiology

4. DMICE is a national leader • No official rankings, but OHSU informatics program is • 1 of 14 programs to have a National Library of Medicine NIH Training Grant for PhD and postdoctoral students • 1 of 9 programs funded under the Office of the National Coordinator Health IT Workforce Development Program • 1 of 8 programs funded by the NIH Fogarty Center Informatics Training for Global Health Program in collaboration with Hospital Italiano de Buenos Aires • Consistent recipient of research funding, appointment to national leadership positions, publication in high-profile journals, etc. • Highly accomplished alumni being productive in many different settings • Clinical epidemiology program also highly successful, especially in areas of evidence-based medicine and comparative effectiveness research

5. And innovator • Early adopter of educational technologies and distance learning • Advancing with the cutting edge of the field • Informatics Discovery Lab – real-world solutions to real-world problems • http://www.ohsu.edu/idl

6. OHSU Biomedical Informatics GraduateProgram • http://www.ohsu.edu/informatics/ • Overall goal of program is to train future professionals, researchers, and leaders in area of biomedical and health informatics • Tracks focus on different areas of larger field • All programs at graduate level, i.e., require a baccalaureate degree • Diverse students who typically fall into one of two categories • “First-career” students more likely to be full-time, on-campus, and from variety of backgrounds • “Career-changing” students likely to be part-time, distance, mostly (though not exclusively) from healthcare professions

7. Program faculty and leadership • Overall program director – William Hersh, MD • Track leaders • William Hersh, MD – Clinical Informatics • Shannon McWeeney, PhD – Bioinformatics & Computational Biology • Joanne Valerius, PhD, RHIA – Health Information Management • Over 30 other faculty who teach, advise, mentor projects, etc.

8. Program tracks • Clinical Informatics • Original track, focused on informatics in health, healthcare, public health, and clinical research settings • Bioinformatics and Computational Biology (BCB) • Focused on informatics in genomics. molecular biology, and their translational research aspects • Health Information Management (HIM) • Intersecting with clinical informatics, focused on HIM profession and leading to Registered Health Information Administrator (RHIA) certification

9. Degrees and certificates • Doctor of Philosophy (PhD) • For those who wish to pursue research, academia, or leadership careers • Master of Science (MS) • Research master’s, including for those with doctoral degrees in other fields who wish to pursue research careers • Master of Biomedical Informatics (MBI) • Professional master’s degree for practitioners and leaders • Graduate Certificate • Subset of master’s degree as an introduction or career specialization

10. Tracks, degrees and certificates, andavailability

11. Curriculum • Curriculum in each track for degree programs (master’s and PhD) organized into domains, each of which may have courses that are • Required • Individual competency (“k of n”) • Elective • Core curriculum of degree programs is knowledge base plus additional courses • MS = knowledge base + thesis • MBI = knowledge base + capstone (can be internship) • PhD = knowledge base + additional advanced work, including dissertation

12. Building block approach PhD - Courses in domains: - Clinical Informatics - Bioinformatics - Knowledge Base - Advanced Research Methods - Biostatistics - Cognate - Doctoral Symposium - Mentored Teaching - Dissertation Masters - Courses in domains: - Clinical Informatics - Bioinformatics - Health Information Management - Thesis or Capstone Graduate Certificate - Courses in domains: - Clinical Informatics - Health Information Management 10x10 - Or introductory course

13. Other programs • Fellowships • Predoctoral and postdoctoral funding from National Library of Medicine, National Institutes of Health, Kaiser Permanente, and others • Clinical informatics fellowship for physicians starting in 2015 • 10x10 (“ten by ten”) • Continuing education course in clinical informatics • Adaptation of on-line introductory course (BMI 510), with option to pursue further study at OHSU • Over 1800 have completed course since 2005, with about 20-25% going on to additional graduate study

14. Overview of all OHSU informatics education Graduate Education Clinical Fellowship Single courses (e.g., 10x10) Graduate Certificate Master’s Degree PhD • For physicians only (for now): ACGME-accredited clinical informatics fellowship, leading to board certification: • Didactic coursework • Project work • Clinical practice NLM and other training grants

15. OHSU informatics program provides value • For tuition and fees comparable to other programs, get • Cutting-edge curriculum based on solid foundation • Faculty who are international leaders in research and practice • Internship/practicum experience • Career development and advising • Connections to industry and others

16. Alumni – 558 people have earned 605 degreesand certificates International students from: Argentina, Singapore, Egypt, Israel, Thailand, Zimbabwe, Saudi Arabia, China, etc.

17. Some job titles and employers • Product manager • Clinical informatics analyst • Informatics researcher • Librarian • Consultant • Project manager • Terminology engineer • Software engineer • Chief medical informatics officer • Information systems manager • Bioinformatician • Data manager • Database administrator/architect • Faculty • OHSU • Providence Health System • Kaiser-Permanente • OCHIN • Impact Advisors • Health Share of Oregon CCO • Epic • Cerner • NextGen • Sutter Health • National Library of Medicine • Harvard Medical School • University of Virginia

18. Clinical Informatics Track • Primary goal of clinical informatics track is to educate the future developers and managers of health care information systems • Individuals with a variety of backgrounds are provided a strong technical grounding in clinical informatics, health and medicine, computer science, and research methods so that they may assume positions that require a thorough understanding of both information technology and the health care environment

19. Domains of clinical informatics • Basic principles of biomedical informatics to problems in different domains of health and biomedicine • Operational knowledge of the human body in health and disease as well as the organization of the health care system • Principles of organizational behavior and management skills to biomedical informatics problems • Basic statistics and quantitative or qualitative research methods to evaluative research projects • Basic computer science principles to problems in health and biomedicine • Students will be adept in the tools of advanced scholarship , including the ability to address ethical issues in the field, communicate effectively in oral and written form, and complete a thesis (MS degree), capstone (MBI degree), or dissertation (PhD degree)

20. Emerging aspects of clinical informatics • Focus shifting from implementing to optimizing clinical informatics systems • Latest buzzword: analytics • In reality, program already offers course content in statistics, healthcare quality, clinical data standards, etc. • New courses and grant projects • For physicians, new subspecialty of clinical informatics • Subspecialty of any primary specialty • Additional certification options likely forthcoming for non-physicians

21. Clinical informatics career pathways havediverse inputs and outputs Health care professions, e.g., medicine, nursing, etc. Biomedical and health informatics education (graduate level) There is no single career pathway, ladder, etc. Natural and life sciences, e.g., biology, genetics, etc. • Jobs in: • Healthcare systems • Clinical leadership • IT leadership • Biomedical research • Industry • Academia Computer science (CS), IT, and undergrad informatics Health information management (HIM) Others, e.g., business, library and info. science

22. Health Information Management Program OHSU Director: Joanne Valerius, PhD, MPH, RHIA valerius@ohsu.edu

23. One Professional’s Viewpoint “Contributing to Health Care Without the Blood and Guts” Lisa Kampa, M.A, RHIA

24. Focus of Program Content • Implementation of EHR. • Data Quality and Information Governance : Available, Accurate, Protected • Privacy and Security • Operational Management and Human Resource Development:

25. Format of Coursework • All coursework is delivered online except for the practical work experience or practicum • The practicum is a minimum of 40 hour in person experience in a healthcare setting to gain practical knowledge in field

26. From Certificate to PhD • The HIM curriculum has met accreditation standards of the Commission for Health Informatics and Health Information education. • Within our programs a student can take the curriculum through the following options: • Certificate • Masters • PhD cognate We need PhD’s in our field– and there are several professorships available

27. Benefit of HIM track completion • At the completion of the program you can sit for the national certification exam. • When you pass the exam, you will have the credential RHIA, Registered Health Information Administrator which is known throughout the U.S. healthcare system. • Continued growth in field due to HIT.

28. HIM Professional Roles Today • HIM professionals serve in various roles, including: • Director/Manager/Supervisor -Health Data Analyst • Researchers and Data Managers -Patient Portal Manager • EHR Trainer/Educator -Data Integrity Specialist • Chief Knowledge Officer -Clinical Vocabulary Manager • Clinical Documentation Specialist -Revenue Management • Educator in Higher Ed -Consultant • Compliance Officer -Privacy/Security Officer • Executive Suite in healthcare and vendor agencies

29. References • AHIMA Advocacy and Public Policy ahima.org/advocacy/default.aspx • Centers for Medicare and Medicaid Services EHR Incentive Programs cms.gov/EHRIncentivePrograms/ • Health IT Buzz Blog healthit.hhs.gov/blog/onc • Office of the National Coordinator healthit.hhs.gov/portal/server.pt • Health Information Career Pathfinder hicareers.com/Toolbox/pathways.aspx • Health Information Management Concepts, Principles, and Practice, 4th Edition • Bureau of Labor Statistics bls.gov/oco/cg/cgs035.htm

30. Bioinformatics and Computational Biology Track

31. Definition of Biomedical Informatics Broad field: focused on the use of information and technology in health and biomedicine. Clinical Informatics Focus on clinical medicine & health care. Bioinformatics Focus on issues in genomics, molecular and computational biology Emphasis on @OHSU on Translational Bioinformatics

32. Clinical Genomics: Individualized Therapy in Leukemia • AML: Acute myeloid leukemia • Need for novel therapies: current treatments very toxic and relapse is frequent outcome • Utilizing Next Generation Sequencing, siRNA and small molecule screens to identify drug targets • A template for personalized medicine in cancer Dr. Brian Druker Director, OHSU Knight Cancer Institute Developed Gleevec one of first targeted cancer therapies

33. Clinical Genomics: Rationale for Multi-OMICS RNA-seq: Actionable overexpression DNA and RNA Genomic variation in DNA: Nothing actionable Source: NY Times

34. BCB Focus: Translational Bioinformatics • Transform exponentially growing genetic, genomic, and biological data into diagnostics and therapeutics • Developcomputational approaches for • Data representation, annotation, and management • Analysis and Integration • Modeling, interpretation, and prediction • Active areas of study in the BCB track: • data analysis and integration for functional genomics • systems modeling for in silico hypothesis generation/prediction • text mining and information retrieval • imaging and computational neuroscience.

35. Big Data in Computational Biology Source:Roland Krause

36. Personalized Medicine Source: Clinical Pharmacology & Therapeutics

37. Curriculum – Objectives • Train students to become sophisticated, interdisciplinary researchers and/or practitioners applying state-of-the-art computational methods to advance biological discovery • Enable them to apply their skills to a variety of jobs in academic, hospital, and industry settings.

38. BCB Core Sequence (Year 1) • Bioinformatics and Computational Biology I: Algorithms • Algorithm development and application to biological problems • Class projects with data “hot off the presses” • Bioinformatics and Computational Biology II: Statistical Methods • Problem driven examination of quantitative issues in computational biology • Hands-on to allow integration and synthesis of concepts

39. BCB Core Sequence (Year 1 & 2) • Computational Genetics (Year 2) • Bioinformatics and statistical concepts relating to genetic and genomic research questions • Examine data types used in high-throughput experiments • Discuss the lab experiments in the context of how the procedures impact the data generated • Experience with current databases used to store data types • Current topics in Computational Biology (Year 1) • Cutting-edge topics in the field (changes every year) • Some past topics: Systems Biology, Pharmacogenomics, Noncoding Genome

40. Research Experience for BCB (Year 1) • BMI 552 Research in BCB • 10 week project co-mentored by basic scientist or clinician and DMICE faculty • Provides “hands-on”, on-site experience during your training • Internship opportunities: OCTRI, Knight Cancer Institute, PARC (internal) and Institute for Systems Biology, Pacific Biosciences etc (external)

41. Analysis vs. Synthesis • Graduate student mindset • Independent thinking: synthesis www.phdcomics.com

42. Interaction with Peers, Advisor and Faculty • Chalk talks

43. Career Advice • Erase mental “barriers” • View your coursework as valuable – skills you can use and master • Don’t be afraid to ask questions • Feed your mind – this is a life long process • Don’t be afraid of change • Seek out research and volunteer opportunities – it will help you clarify what you are drawn to for possible career areas • Best path is one that you are good out, that you are passionate about and that is sustainable Slide: S McWeeney

44. Blog, tweet, share, like and other good stuff Chirpstory: Cold Spring Harbor Meeting • Emerging BCB culture • social interaction • open source • PLoS • SeqAnswers • ENCODE project www.facebook.com/OHSUBioinformatics www.twitter.com/OHSUBCB

45. Logistics

46. Student progress • Faculty are very busy BUT students are a top priority • They will state best way to contact them at beginning of course or advising, which is usually email • Program staff provide additional help and tools (e.g., forecasting sheets) • Faulty should respond to simple matters via email within two business days • More detailed responses may require meeting and/or involvement of program staff

47. Key Program Personnel • Diane Doctor, Student Support and Internship Coordinator • Email: doctord@ohsu.edu • Office: BICC 504, Office phone: 503-494-4794 • Sarah Melton, Sakai Support • Email: sakai@ohsu.edu Office SON 476 • Office: 503-494-7074 Toll Free: 877-972-5249 • Office: BICC 404, Office phone: 503-494-2494 • Virginia Lankes, Career Development Coordinator • Email: lankes@ohsu.edu • Office: BICC 404, Office phone: 503-494-2331

48. Key Program Personnel • Lynne Schwabe, Administrative Assistant • Email: schwabel@ohsu.edu • Office: BICC 504, Office phone: 503-418-1566 • Lauren Ludwig, Recruiting/Admissions • Email: ludwigl@ohsu.edu • Office: BICC 404, Office phone: 503-494-2252 • Andrea Ilg, Educational Program Administrator • Email: ilgan@ohsu.edun@ohsu.edu • Office: BICC 504, Office phone: 503-494-2547

49. Weekly Informatics Conference • Place to learn about new developments in field and project/employment opportunities. • Forum for students to present dissertation/thesis proposals, /dissertation/thesis defenses and research in progress. • Thursdays in BICC 124 (Theater) at 11:30 am (may change due to availability of speakers). • Attendance is taken – you are strongly encouraged to attend. • Pizza will be served, remember to RSVP to Lynne. • Presentations are recorded and posted to our You Tube channel https://www.youtube.com/channel/UCCekPERb6i3xXEDQxwlCeIA

50. Registration/Course Planning • Complete registration online. Instructions available on the “Student Resources” page • Course schedules are provided on the flash drive as well as on the online registration web page. • Forecasting worksheets are included on the flash drive and can be used as guidelines for planning your schedule. • 9.0+ credits = full-time student status. • 5.0 credits = part-time student status.