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In the name of God

MCTD, Overlap, UCTD. RRC. In the name of God. Mixed connective tissue disease Overlap syndrome Undifferentiated connective tissue disease. I. Salehi. MCTD, Overlap, UCTD. RRC. In the name of God. Mixed connective tissue disease Overlap syndrome

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In the name of God

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  1. MCTD, Overlap, UCTD RRC In the name of God Mixed connective tissue disease Overlap syndrome Undifferentiated connective tissue disease I. Salehi

  2. MCTD, Overlap, UCTD RRC In the name of God Mixed connective tissue disease Overlap syndrome Undifferentiated connective tissue disease I. Salehi

  3. MCTD, Overlap, UCTD RRC In the name of God Mixed connective tissue disease Overlap syndrome Undifferentiated connective tissue disease I. Salehi

  4. MCTD, Overlap, UCTD RRC In the name of God Mixed connective tissue disease Overlap syndrome Undifferentiated connective tissue disease I. Salehi

  5. MCTD, Overlap, UCTD RRC Diseases Classification: • Six major Rheumatic diseases • Systemic Lupus Erythematosus(SLE) • Scleroderma(Scl) • Polymyositis(PM) • Dermatomyositis(DM) • Rheumatoid Arthritis(RA) • Primary Sjogren’s syndrome I. Salehi

  6. MCTD, Overlap, UCTD RRC Diseases Classification: • Six major Rheumatic diseases • Systemic Lupus Erythematosus(SLE) • Scleroderma(Scl) • Polymyositis(PM) • Dermatomyositis(DM) • Rheumatoid Arthritis(RA) • Primary Sjogren’s syndrome I. Salehi

  7. MCTD, Overlap, UCTD RRC Diseases Classification: • Six major Rheumatic diseases • Systemic Lupus Erythematosus(SLE) • Scleroderma(Scl) • Polymyositis(PM) • Dermatomyositis(DM) • Rheumatoid Arthritis(RA) • Primary Sjogren’s syndrome I. Salehi

  8. MCTD, Overlap, UCTD RRC Diseases Classification: • Six major Rheumatic diseases • Systemic Lupus Erythematosus(SLE) • Scleroderma(Scl) • Polymyositis(PM) • Dermatomyositis(DM) • Rheumatoid Arthritis(RA) • Primary Sjogren’s syndrome I. Salehi

  9. MCTD, Overlap, UCTD RRC Diseases Classification: • Six major Rheumatic diseases • Systemic Lupus Erythematosus(SLE) • Scleroderma(Scl) • Polymyositis(PM) • Dermatomyositis(DM) • Rheumatoid Arthritis(RA) • Primary Sjogren’s syndrome I. Salehi

  10. MCTD, Overlap, UCTD RRC Diseases Classification: • Six major Rheumatic diseases • Systemic Lupus Erythematosus(SLE) • Scleroderma(Scl) • Polymyositis(PM) • Dermatomyositis(DM) • Rheumatoid Arthritis(RA) • Primary Sjogren’s syndrome I. Salehi

  11. MCTD, Overlap, UCTD RRC Diseases Classification: • Six major Rheumatic diseases • Systemic Lupus Erythematosus(SLE) • Scleroderma(Scl) • Polymyositis(PM) • Dermatomyositis(DM) • Rheumatoid Arthritis(RA) • Primary Sjogren’s syndrome I. Salehi

  12. MCTD, Overlap, UCTD RRC Diseases Classification: • Six major Rheumatic diseases • Systemic Lupus Erythematosus(SLE) • Scleroderma(Scl) • Polymyositis(PM) • Dermatomyositis(DM) • Rheumatoid Arthritis(RA) • Primary Sjogren’s syndrome I. Salehi

  13. MCTD, Overlap, UCTD RRC • Diffuse Connective Tissue Disease (DCTD) • Diffuse Systemic Rheumatic Disease • Well-differentiated connective tissue disease I. Salehi

  14. MCTD, Overlap, UCTD RRC • Diffuse Connective Tissue Disease (DCTD) • Diffuse Systemic Rheumatic Disease • Well-differentiated connective tissue disease I. Salehi

  15. MCTD, Overlap, UCTD RRC • Diffuse Connective Tissue Disease (DCTD) • Diffuse Systemic Rheumatic Disease • Well-differentiated connective tissue disease I. Salehi

  16. MCTD, Overlap, UCTD RRC • Early Undifferentiated Connective Tissue Disease • Undifferentiated Connective Tissue Disease • Mixed Connective Tissue Disease • Some features of > 2 of DCTD • High titer Anti-U1RNP • Overlap Syndrome • Rhupus(RA+SLE) • Psupus(Psoriatic A.+ SLE) I. Salehi

  17. MCTD, Overlap, UCTD RRC • Early Undifferentiated Connective Tissue Disease • Undifferentiated Connective Tissue Disease • Mixed Connective Tissue Disease • Some features of > 2 of DCTD • High titer Anti-U1RNP • Overlap Syndrome • Rhupus(RA+SLE) • Psupus(Psoriatic A.+ SLE) I. Salehi

  18. MCTD, Overlap, UCTD RRC • Early Undifferentiated Connective Tissue Disease • Undifferentiated Connective Tissue Disease • Mixed Connective Tissue Disease • Some features of > 2 of DCTD • High titer Anti-U1RNP • Overlap Syndrome • Rhupus(RA+SLE) • Psupus(Psoriatic A.+ SLE) I. Salehi

  19. MCTD, Overlap, UCTD RRC • Early Undifferentiated Connective Tissue Disease • Undifferentiated Connective Tissue Disease • Mixed Connective Tissue Disease • Some features of > 2 of DCTD • High titer Anti-U1RNP • Overlap Syndrome • Rhupus(RA+SLE) • Psupus(Psoriatic A.+ SLE) I. Salehi

  20. MCTD, Overlap, UCTD RRC MCTD: • History: • Was originally defined in 1972 • Epidemiology: • F / M ratio : 16 / 1 • Second or third decades I. Salehi

  21. MCTD, Overlap, UCTD RRC MCTD: • History: • Was originally defined in 1972 • Epidemiology: • F / M ratio : 16 / 1 • Second or third decades I. Salehi

  22. MCTD, Overlap, UCTD RRC Initial presentation(MCTD) • Arthralgia • Myalgia • Malaise • Fatigue • Low grade fever I. Salehi

  23. MCTD, Overlap, UCTD RRC Initial presentation(MCTD) • Arthralgia • Myalgia • Malaise • Fatigue • Low grade fever I. Salehi

  24. MCTD, Overlap, UCTD RRC Initial presentation(MCTD) • Arthralgia • Myalgia • Malaise • Fatigue • Low grade fever I. Salehi

  25. MCTD, Overlap, UCTD RRC Initial presentation(MCTD) • Arthralgia • Myalgia • Malaise • Fatigue • Low grade fever I. Salehi

  26. MCTD, Overlap, UCTD RRC Initial presentation(MCTD) • Arthralgia • Myalgia • Malaise • Fatigue • Low grade fever I. Salehi

  27. MCTD RRC Skin & Mucousal involvement • Raynaud’s phenomenon • Swollen & puffy hand • Sclerodactyly • Calcinosis cutis • Discoid rash • Malar rash • Oral & Genital ulcer • Nasal septal perforation • Sicca complex I. Salehi

  28. MCTD RRC Skin & Mucousal involvement • Raynaud’s phenomenon • Swollen & puffy hand • Sclerodactyly • Calcinosis cutis • Discoid rash • Malar rash • Oral & Genital ulcer • Nasal septal perforation • Sicca complex I. Salehi

  29. MCTD RRC Skin & Mucousal involvement • Raynaud’s phenomenon • Swollen & puffy hand • Sclerodactyly • Calcinosis cutis • Discoid rash • Malar rash • Oral & Genital ulcer • Nasal septal perforation • Sicca complex I. Salehi

  30. MCTD RRC Skin & Mucousal involvement • Raynaud’s phenomenon • Swollen & puffy hand • Sclerodactyly • Calcinosis cutis • Discoid rash • Malar rash • Oral & Genital ulcer • Nasal septal perforation • Sicca complex I. Salehi

  31. MCTD RRC Skin & Mucousal involvement • Raynaud’s phenomenon • Swollen & puffy hand • Sclerodactyly • Calcinosis cutis • Discoid rash • Malar rash • Oral & Genital ulcer • Nasal septal perforation • Sicca complex I. Salehi

  32. MCTD RRC Skin & Mucousal involvement • Raynaud’s phenomenon • Swollen & puffy hand • Sclerodactyly • Calcinosis cutis • Discoid rash • Malar rash • Oral & Genital ulcer • Nasal septal perforation • Sicca complex I. Salehi

  33. MCTD RRC Skin & Mucousal involvement • Raynaud’s phenomenon • Swollen & puffy hand • Sclerodactyly • Calcinosis cutis • Discoid rash • Malar rash • Oral & Genital ulcer • Nasal septal perforation • Sicca complex I. Salehi

  34. MCTD RRC Skin & Mucousal involvement • Raynaud’s phenomenon • Swollen & puffy hand • Sclerodactyly • Calcinosis cutis • Discoid rash • Malar rash • Oral & Genital ulcer • Nasal septal perforation • Sicca complex I. Salehi

  35. MCTD RRC Skin & Mucousal involvement • Raynaud’s phenomenon • Swollen & puffy hand • Sclerodactyly • Calcinosis cutis • Discoid rash • Malar rash • Oral & Genital ulcer • Nasal septal perforation • Sicca complex I. Salehi

  36. MCTD RRC Musculoskeletal: • Oligo & Polyarthritis: %60 • Severity: SLE<MCTD<RA • Swan neck & Boutonniere • Jaccoud’s arthropathy • Small marginal erosion • Mutilan arthritis: rare • RF: %70 • Myopathy & Myositis I. Salehi

  37. MCTD RRC Musculoskeletal: • Oligo & Polyarthritis: %60 • Severity: SLE<MCTD<RA • Swan neck & Boutonniere • Jaccoud’s arthropathy • Small marginal erosion • Mutilan arthritis: rare • RF: %70 • Myopathy & Myositis I. Salehi

  38. MCTD RRC Musculoskeletal: • Oligo & Polyarthritis: %60 • Severity: SLE<MCTD<RA • Swan neck & Boutonniere • Jaccoud’s arthropathy • Small marginal erosion • Mutilan arthritis: rare • RF: %70 • Myopathy & Myositis I. Salehi

  39. MCTD RRC Musculoskeletal: • Oligo & Polyarthritis: %60 • Severity: SLE<MCTD<RA • Swan neck & Boutonniere • Jaccoud’s arthropathy • Small marginal erosion • Mutilan arthritis: rare • RF: %70 • Myopathy & Myositis I. Salehi

  40. MCTD RRC Musculoskeletal: • Oligo & Polyarthritis: %60 • Severity: SLE<MCTD<RA • Swan neck & Boutonniere • Jaccoud’s arthropathy • Small marginal erosion • Mutilan arthritis: rare • RF: %70 • Myopathy & Myositis I. Salehi

  41. MCTD RRC Musculoskeletal: • Oligo & Polyarthritis: %60 • Severity: SLE<MCTD<RA • Swan neck & Boutonniere • Jaccoud’s arthropathy • Small marginal erosion • Mutilan arthritis: rare • RF: %70 • Myopathy & Myositis I. Salehi

  42. MCTD RRC Musculoskeletal: • Oligo & Polyarthritis: %60 • Severity: SLE<MCTD<RA • Swan neck & Boutonniere • Jaccoud’s arthropathy • Small marginal erosion • Mutilan arthritis: rare • RF: %70 • Myopathy & Myositis I. Salehi

  43. MCTD RRC Musculoskeletal: • Oligo & Polyarthritis: %60 • Severity: SLE<MCTD<RA • Swan neck & Boutonniere • Jaccoud’s arthropathy • Small marginal erosion • Mutilan arthritis: rare • RF: %70 • Myopathy & Myositis I. Salehi

  44. MCTD RRC Heart: • Pericarditis(most common) • Myocarditis • Hypertensive heart • ECG : • RVH • RAE • Intraventricular conduction defect I. Salehi

  45. MCTD RRC Heart: • Pericarditis(most common) • Myocarditis • Hypertensive heart • ECG : • RVH • RAE • Intraventricular conduction defect I. Salehi

  46. MCTD RRC Heart: • Pericarditis(most common) • Myocarditis • Hypertensive heart • ECG : • RVH • RAE • Intraventricular conduction defect I. Salehi

  47. MCTD RRC Heart: • Pericarditis(most common) • Myocarditis • Hypertensive heart • ECG : • RVH • RAE • Intraventricular conduction defect I. Salehi

  48. MCTD RRC Lungs: • Asymptomatic • Interstitial Lung Disease:%67 • Pleural effusion • Pulmonary infiltration • Pulmonary hypertension I. Salehi

  49. MCTD RRC Lungs: • Asymptomatic • Interstitial Lung Disease:%67 • Pleural effusion • Pulmonary infiltration • Pulmonary hypertension I. Salehi

  50. MCTD RRC Lungs: • Asymptomatic • Interstitial Lung Disease:%67 • Pleural effusion • Pulmonary infiltration • Pulmonary hypertension I. Salehi

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