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AnoXcell in AnoBase

AnoXcell in AnoBase. 2001 – 2010 Decade to Roll Back Malaria (WHO) 300 million acute cases - 1 million deaths / year Africa: 500k children / 20% die / 7% PND Vaccines (40% delay) /Insecticide treated net (ITNs). Figure 1 Overview of Ensembl Gene Build. O RepeatMasker O GeneScan

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AnoXcell in AnoBase

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  1. AnoXcell in AnoBase

  2. 2001 – 2010 Decade to Roll Back Malaria (WHO) • 300 million acute cases - 1 million deaths / year • Africa: 500k children / 20% die / 7% PND • Vaccines (40% delay) /Insecticide treated net (ITNs)

  3. Figure 1 Overview of Ensembl Gene Build O RepeatMasker O GeneScan O tRNAscan O BLAST searches

  4. AnoBase Gene tool • Known status • Known symbol • Predicted genes

  5. AnoXcel

  6. Met @ position 1 - 20

  7. MW and pI calculated from individual values for each aa Frequency of each aa in proteome. BLAST vs NR BLAST vs GO BLAST vs SMART BLAST vs PFAM BLAST vs COG BLAST vs KOG BLAST vs Drosophila BLAST vs C. elegans BLAST vs Human BLAST vs Anopheles AnoXcel sections

  8. Clustering via blastp • Blastp vs the database itself • Join criteria as described per category • Gaps are calculated before 2 proteins to be joined in the same cluster.

  9. Things to be done • Full incorporation of ENSEMBL’s genes submitted by the community • AnoEST • Integration of the tool into Vectorbase

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