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“Depression and type 2 diabetes: Cortisol pathway implication and investigational needs”

“Depression and type 2 diabetes: Cortisol pathway implication and investigational needs”. Claudia Gragnoli Journal Club 3. The Paper. Why this one? Psychiatry Depression Atypical Major Depression Endocrinology T2DM HPA axis What is known and what links are there?. The HPA axis.

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“Depression and type 2 diabetes: Cortisol pathway implication and investigational needs”

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  1. “Depression and type 2 diabetes: Cortisol pathway implication and investigational needs” Claudia Gragnoli Journal Club 3

  2. The Paper • Why this one? • Psychiatry • Depression • Atypical • Major Depression • Endocrinology • T2DM • HPA axis • What is known and what links are there?

  3. The HPA axis

  4. CRH receptors • CRHR2 • Sustaining HPA function • Recovery Phase of HPA response • CRHR1 • HPA axis Development • Initiation of HPA axis response • Behaviour/Anxiety • (Limbic) HPA feedback Brainstem to release catecholamines/ adrenaline Anxiety

  5. T2DM and cortisol

  6. Depression and cortisol

  7. T2DM and Depression • 60% risk of diabetes if you have major depression • No known link but...

  8. T2DM and Depression • Atypical Depression patients so no raise in cortisol but still are at risk of T2DM

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