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Nano- Dendrimers Used in Drug Delivery

Nano- Dendrimers Used in Drug Delivery . Pb09207223 张馨元 Pb10206066 张希良 Pb10207016 高绪远. Outline. Why dendrimers ? What is dendrimers ? How it works? Cytotoxicity Conjecture. Structures for Drug Delivery . Liner polymers Larger nanoparticles Liposomes.

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Nano- Dendrimers Used in Drug Delivery

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  1. Nano-Dendrimers Used in Drug Delivery Pb09207223 张馨元 Pb10206066 张希良 Pb10207016 高绪远

  2. Outline • Why dendrimers? • What is dendrimers? • How it works? • Cytotoxicity • Conjecture

  3. Structures for Drug Delivery • Liner polymers • Larger nanoparticles • Liposomes http://www.sciencedirect.com/science/article/pii/S1740674905000107 http://trialx.com/curetalk/2012/10/nanotechnology-drug-delivery-systems-an-insight/ https://sitn.hms.harvard.edu/sitnflash_wp/2011/06/materials-for-drug-delivery/

  4. What is dendrimers? • Dendrimersare used as well-defined scaffolding or nanocontainers to conjugate, complex or encapsulate therapeutic drugs or imaging moieties.

  5. What is dendrimers? http://www.nanotechnologies.qc.ca/projects/nanopatterning/nanopatterning

  6. What is dendrimers? http://www.pharmainfo.net/reviews/dendrimer-overview

  7. What is dendrimers? AnupaR. Menjoge et. al, Drug Discovery Today, 2010

  8. How it works?

  9. Cytotoxicity • Concentration • Generation • Surface charge dependent

  10. Conjecture

  11. ?

  12. Hybrid tree • If we combine two of the branches of the core with some other small molecules which can be easily hydrolyzed to release the active site of the core…

  13. Parrott, M. C.; Benhabbour, S. R.; Saab, C.; Lemon, J. A.; Parker, S.; Valliant, J. F.; Adronov, A. J. Am. Chem. Soc.2009, 131, 2906-2916.

  14. Sub-Hybrid Tree • If we add some other surface molecules which can combine the pre- surface, When the generation is over 4…

  15. New cocktail? • We know that the release of physically entrapped guest-type drugs in dendrimeric hosts might be controlled by both surface modification and the density of modifying groups. • Well , what can we do?

  16. Thanks!

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