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Breast Cancer

Breast Cancer. Hereditary (genes) and how it is passed down (Inheritance). Works Cited. Brody L., and Bowles B., 1998. Breast cancer susceptible genes BRCA1 and BRCA2. Medicine 77:208-26. Ormiston W. 1995. Hereditary breast cancer. European Journal of cancer care. 5, 13-20.

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Breast Cancer

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  1. Breast Cancer Hereditary (genes) and how it is passed down (Inheritance)

  2. Works Cited • Brody L., and Bowles B., 1998. Breast cancer susceptible genes BRCA1 and BRCA2. Medicine 77:208-26. • Ormiston W. 1995. Hereditary breast cancer. European Journal of cancer care. 5, 13-20. • Social and Ethical issues of breast cancer gene testing. Obtain form htt://www.negr.org/gpi/odyssey/BCAN2/grest.html0/29/98. • K-Kinzler, Kenneth W., and Vogelstein, Bert. 1997. Breast cancer susceptibility genes BRCA1 and BRCA2. Nature. V. 386. 761-763. • Marx, Jean. 1997 Possible function found for breast cancer genes Science vol. 276 531-532.

  3. More Work Cited • McCain, L., and Dilligham, C., 1997. Genetics Mutation Associated with Breast Cancer. Obtain from http://www.ncgr.org/gpi/odyssey/BCAN2?genrisk.gtml 10/12/98 • Tumor suppressor gene” obtain from http://www.eb.com:180> 10/19/98, search word: tumor suppressor gene. • Breast and/or ovarian cancer risk in Jewish women: Role of the 185delAG and other mutations in the BRCA1 and BRCA2 genes. http://www.givf.com/brcal.html 10/12/98

  4. What is breast cancer? • Breast Cancer a malignant ( an abnormal growth that tends to spread) Neoplasm (a new and abnormal formation of tissue, as a tumor or growth serves no useful function).

  5. The two major genes of breast cancer they are called : BRCA1 and BRCA2 • A. BRCA1 is a breast cancer gene that is found in a small percentage of patients with this malignancy, and carried by some individuals who will develop breast cancer later in life. • B. BRCA2 is a breast cancer gene found in a small number of patients with breast and ovarian (concerning or resembling the ovary, egg of female) cancers, and carried by some individuals who will develop breast cancer later in life.

  6. The differences between BRCA1 and BRCA2 • There is a high incidence ( the area of distance over which a thing extends) of ovarian cancer to BRCA1, but in BRCA2 gene is associated (connects) with very low incidence of ovarian cancer.

  7. How BRCA1 and BRCA2 are similar: • In BRCA1 and BRCA2 first they both contain a region that can act as a transcriptional ( the act of process of transcribing) activation domain when it’s fused (to mix together) with DNA binding domain ( a territory over which control is exercised) form another gene. • Second similarity is that BRCA1 and BRCA2 bind to Rad5 (Radiation absorbed dose) protein that is involved in maintain the integrity of the genome ( genetic material contained in a haploid set of chromosomes in eukaryotes, in a single chromosome in bacteria or in the DNA or RNA of viruses.

  8. Breast Cancer in Women • The most effected cancer in the United States is breast cancer in women. • Leading cause of American women ages 40 to 50.(12% Incidence (occurrence) of breast cancer. • More than two-thirds of women affected by it are now cured.

  9. Breast Cancer In Men • Men carrying BRCA1 have no risk to develop breast cancer. • Men carrying BRCA2 genes have high risk. • About 1,000 men are diagnosed (examined) with breast cancer annually ( frequently).

  10. Risk factors for Breast Cancer • Family history of breast cancer ( could be in mother, sister daughter, or two or more close relatives). • Women who had their first child after age 30. • women who have never given birth are at high risk ( endanger) • Any women who had their period before age 12( Menstrual period). • White women are likely to develop breast cancer than black women,but blacks are more likely to die of it then white women and Hispanics and Asian women have a lower risk of getting the disease.

  11. Symptoms of Breast Cancer • A dominant ( most prominent, as in position) breast mass, bloody, brown or serous discharge form a nipple; and breast cancer. • Diet in fat and calories. • smoking • exposure to environmental toxins. • Pesticides, exposure to various (lots) hormones. • lack of exercise • exposure to sunlight and other kinds of Radiation.

  12. To prevent Breast Cancer There is Mammography (X-ray examination of the breast for detection (checking) of tumors) and annual (often) clinical breast examination.

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