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Framework for Rapid Prioritization

Framework for Rapid Prioritization. Linda Sheldon, Ph.D. Associate Director, National Exposure Research Laboratory April 6, 2010. The Challenge. “Assure chemical safety in a rapidly changing world” Too many chemicals too little data 75,000 chemicals in TSCA inventory

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Framework for Rapid Prioritization

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  1. Framework for Rapid Prioritization Linda Sheldon, Ph.D. Associate Director, National Exposure Research Laboratory April 6, 2010

  2. The Challenge • “Assure chemical safety in a rapidly changing world” • Too many chemicals too little data • 75,000 chemicals in TSCA inventory • 500 – 1000 new chemicals each year • Must modernize and strengthen the tools available for testing and prioritization • Based on hazard and exposure • Based on sound science • Must be transparent and understandable

  3. The Research Goal • To develop innovative approaches, tools, and enhanced scientific understanding to rapidly and effectively prioritize chemicals for further safety testing based on exposure

  4. The Research Approach • Develop a framework for chemical exposures • Align current databases, data collection protocols, and prioritization tools within the framework • Evaluate and compare existing prioritization tools • ID crucial gaps in our knowledge, data, approaches, and tools • Conduct scientific research to fill these gaps

  5. Framework Requirements Identify the chemicals and the scenarios associated with the highest exposures to categorize chemicals for further testing • Chemicals once created must go someplace • Evaluate release/exposures for chemicals across their life cycles • Account for physico-chemical properties and stability of • Chemical/intermediates • Environmental degradates • Metabolites – for in vitro assays such as Tox Cast • Incorporate spatial scales • Give special consideration to susceptible populations, especially children

  6. Life Cycle Stages Chemical Manufacture Chemical Transport Product Formulation Product Use Disposal Recycle

  7. RELEASE FATE/TRANSPORT CONCENTRATION ACTIVITY EXPOSURE Production Phases Chemical Manufacture WorkplaceExposure Water HumanExposure Food Chemical Transportation EnvironmentalRelease Land A C T I V I T I E S Air Production/Formulation(Product orProcessing Aid) EnvironmentalDisposal Incineration Recycling SewageTreatment PRODUCT USE SCENARIOS

  8. GLOBAL COUNTRY REGION LOCAL ENVIRONMENT backgroundconcentrations inflowconcentrations exchange Incorporation of Spatial Scales-- Environmental Release Based on: Uniform System for the Evaluation of Substances v.4.0, 2002

  9. RELEASE FATE/TRANSPORT CONCENTRATION ACTIVITY EXPOSURE Release Transport Reaction Market Share Population Location Frequency Timing Product Use Scenarios PRODUCT 1 CONSUMERUSE IndoorAir PRODUCT 2 OutdoorAir PRODUCT 3 HumanExposure SurfaceDust PRODUCT 4 PRODUCT 5 Soil A C T I V I T I E S PRODUCT 6 PRODUCT 7 Water PRODUCT 8 Food PRODUCT … Disposal PRODUCT n

  10. Near- and Mid Field Exposures Cleaning, Personal Care, Hobby products NEAR-FIELD

  11. Product Disposal RELEASE FATE / TRANSPORT CONCENTRATION ACTIVITY EXPOSURE Water ProductDisposal EnvironmentalRelease Air HumanExposure A C T I V I T I E S Land Food

  12. PRODUCT 1 PRODUCT 2 PRODUCT 3 PRODUCT 4 PRODUCT 5 Market Share Population PRODUCT 6 Location Frequency PRODUCT 7 Timing PRODUCT 8 PRODUCT … PRODUCT n RELEASE FATE / TRANSPORT CONCENTRATION ACTIVITY EXPOSURE WorkplaceExposure Chemical Manufacture Water FRAMEWORK Food EnvironmentalRelease Chemical Transportation HumanExposure Land A C T I V I T I E S Air Production/Formulation EnvironmentalDisposal Incineration Intermediates Recycling SewageTreatment Chemical ProductUse Degradates IndoorAir OutdoorAir Release Transport HumanExposure SurfaceDust Reaction Soil A C T I V I T I E S Water Food Disposal Water HumanExposure Product Disposal EnvironmentalRelease A C T I V I T I E S Air Land Food

  13. Summary • Framework is critical • Understand what we need, what we have, and identify gaps • Provides a basis for communications • Provides a systematic approach for developing and evaluating tools, databases, and protocols • Supports screening and higher tier models • Allows an evaluation of trade off – energy, land use, etc.

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