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Fast Casters – Project Update March 16, 2006

Fast Casters – Project Update March 16, 2006. Rene Chen Byron Hsu Kimberly Kam Kelsey Vandermeulen Lisa Witmer. Powder Formulation Components. PCL: polycaprolactone C 6 H 10 O 2 PLGA: poly(lactide-co-glycolide) (C 6 H 8 O 4 ) x (C 4 H 4 O 4 ) y TCP: tricalcium phosphate Ca 3 (PO 4 ) 2

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Fast Casters – Project Update March 16, 2006

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  1. Fast Casters – Project UpdateMarch 16, 2006 Rene Chen Byron Hsu Kimberly Kam Kelsey Vandermeulen Lisa Witmer

  2. Powder Formulation Components • PCL: polycaprolactone • C6H10O2 • PLGA: poly(lactide-co-glycolide) • (C6H8O4)x(C4H4O4)y • TCP: tricalcium phosphate • Ca3(PO4)2 • HA: hydroxyapatite • Ca5(PO4)3OH

  3. Update from Formal Design Review • Modulus ranges for individual materials • PCL: 0.5-1 GPa • PGA: ~8 GPa • PLA: 2-3 GPa • HA: 7-13 GPa • Modulus for scaffold structures • ~0.001 GPa

  4. Initial Goals • Characterize current composition • 30% sucrose • 30% lactose • 20% TCP • 20% PLGA • Solid structures

  5. Solidworks Test Samples Tension • Drew up SolidWorks files • Printed tension specimens Compression

  6. Mechanical Testing • Used Yin Lin’s Instron • Automatic grips • Controlled by air pressure • Too high • Manual grips • Work for our samples • Noisy, inaccurate data

  7. Instron Test Results • Young’s Modulus: E = Estress/Estrain = 280 KPa • Failure Stress = 26.6 KPa • Yield Stress = 20.9 KPa • Engineering Stress = force/area • Engineering Strain = displacement / original length

  8. Future Mechanical Testing Candidates • Look at different methods of testing • Nanoindentation • Problematic microstructure • Would need too large of an indenter • 3- or 4- point bending tests • Will not reduce materials usage • MicroTester Instron • Best option

  9. MicroTester InstronMechanical Testing • MicroTester benefits • Smaller load cell (10N) • Smaller sample size = less materials and printing time • Automated as opposed to manual • Made appt. to test next week (thanks to Alan Schwartzman)

  10. SEM Imaging

  11. X-Ray Spectra PGLA Tricalcium Phosphate

  12. Additional Progress • Polymer dispersion process • Started on PCL • Received HA order • Placed order for beta-TCP

  13. Next Steps • Test more samples • Tension and compression • A range of formulations (using HA) • SolidWorks test files for MicroTester • MicroTester testing • Waffle structure in test specimens

  14. Project Timeline

  15. Questions?

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