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14.4 Gene Mutations

14.4 Gene Mutations. What is a Mutation?. A mutation is any change in the amount or structure of the DNA of an organism. KEY POINT: If this occurs in somatic (body) cells, the change cannot be inherited. Only mutations in the DNA within gametes can be passed on to the next generation.

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14.4 Gene Mutations

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  1. 14.4 Gene Mutations

  2. What is a Mutation? • A mutation is any change in the amount or structure of the DNA of an organism. KEY POINT: If this occurs in somatic (body) cells, the change cannot be inherited. Only mutations in the DNA within gametes can be passed on to the next generation.

  3. Causes of Mutations • Mutations occur naturally and at random. • However, mutagens are environmental factors that increase rate of mutation. High-energy radiation Mutagenic chemicals High-energy particles from radioactive substances Carcinogenic substances such as tar and asbestos

  4. Gene Mutations

  5. Point Mutations These are point mutations involving a change of only one nucleotide at a particular locus. There are 3 types: • Substitution One nucleotide is replaced by another with a different base. • Addition An extra nucleotide is added so an extra base is added to the sequence. • Deletion One nucleotide is removed.

  6. Substitutions Substitutions only affect one codon in a sequence of genetic material. They therefore only affect the outcome of a single amino acid. The above animation is a worst case scenario when it comes to substitution mutations. Why might a substitution mutation not have an effect on protein shape at all? T G C T A G T A A C G T A Serine Arginine Tyrosine Tyrosine Alanine

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