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List different movements/motion that occur inside an organism

Session I – How things move inside a cell 2/7/14. List different movements/motion that occur inside an organism. A typical highway road map. Transport road map of a cell. http://www.youtube.com/watch?v=wJyUtbn0O5Y. Watch (Cell Biology)

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List different movements/motion that occur inside an organism

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  1. Session I – How things move inside a cell 2/7/14 List different movements/motion that occur inside an organism

  2. A typical highway road map

  3. Transport road map of a cell http://www.youtube.com/watch?v=wJyUtbn0O5Y

  4. Watch (Cell Biology) Measure and Quantify (Systems/Quantitative Biology, Physics) Disable (Geneticists) Analysis/Optimization ( Bio-engineering)

  5. An effort to understand how these cytoskeletal motor proteins works inside the cell?

  6. Why study cytoskeletal motor proteins? • To understand how living organisms create motion • Important in every facet of biology • Relevance to medicine

  7. Components of molecular machines – Cytoskeletal motors work on tracks Microtubule track Actin track Motor proteins – Kinesins, Dyneins Motor protein – Myosins

  8. Microtubules maintain “polarity”

  9. Location of the tracks inside the cell Microtubules (red) DNA ( blue) Actin filaments ( green)

  10. + end - end

  11. Kinesin Motor protein

  12. Kinesin functions- 45 human genes • Organelle movement (eg Golgi, ER) • Transport or localization • of RNA/proteins • Mitotic spindle formation • and chromosome formation • Ciliary biogenesis

  13. Activities - Explain/Teach concepts to your peers Group 1 – Kinesin walking models. Discuss in vitro experimental observations http://www.stanford.edu/group/blocklab/kinesin/kinesin.html Group 1 presents on 2/14/14 Group 2 – How the motor proteins (Kinesins and Dyneins) convert chemical energy to mechanical energy Vale review paper Group 3 - How to study and perturb microtubule dynamics in vivo? Discuss an assay system to visualize microtubule plus end growth with fluorescent labelingusing a particular model system Review your own literature Group 2 & 3 presents on 2/21/14

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