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Late Pro-B

Pairing of Ig chains. Autoreactivity. 3. 2. 1. Checkpoints during B Cell Development. μ HC fct ?. LC ?. Stem cell. Early Pro-B. Late Pro-B. Early Pre-B. Late Pre-B. ImmatureB cell. Mature B cell. D → J H. V L → J L. V H → DJ H. The Pre-B Cell Receptor Complex. V λ. J λ.

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Late Pro-B

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  1. Pairing of Ig chains Autoreactivity 3 2 1 Checkpoints during B Cell Development μHCfct? LC ? Stem cell Early Pro-B Late Pro-B Early Pre-B Late Pre-B ImmatureB cell Mature B cell D→JH VL →JL VH →DJH

  2. The Pre-B Cell Receptor Complex Vλ Jλ Cλ B A λLC COO- + H3N unique tails - VpreB VpreB + H3N COO- uniquetails λ5 8 COO- 5 8 + + H3N VH C Cµ1 unique tails N-terminal part of 5 µHC Cµ2 + CDR1 + - CDR3 + - - CDR1 + Cµ3 Ig/Ig CDR2 CDR2 Cµ4 8 VpreB VL + β8-UT of 5 Vettermann et al., Sem. Immunol, 2006

  3. Pairing of Ig chains Autoreactivity 3 2 1 Checkpoints during B Cell Development μHCfct? LC ? Stem cell Early Pro-B Late Pro-B Early Pre-B Late Pre-B ImmatureB cell Mature B cell D→JH VL →JL VH →DJH

  4. miRNA ? VH →D →JH Pre-BCR IL7 Pre-B cells TF ? Stroma cell Stroma cell ↑ mRNA↑ ↑ Protein stability CDK4 D3 Rb P Cell cycle activators D3 P E2F E2F P Rb P P Control of pro-B and pre-B cell expansion Pro-B cells IL7 Clarke Lab, Chicago Nature Immunollgy 2006

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