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BP management Rationale for combination therapy

BP management Rationale for combination therapy. BP lowering Drug Efficacy - Monotherapy. Law MR, et al. BMJ 2003. The importance of combination therapy. Van Swieten PA. ESC Scientific Newsletter 2003; 4 : 1 –2. Chobanian AV, et al. JAMA 2003; 289 (19): 2560–2572.

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BP management Rationale for combination therapy

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  1. BP managementRationale for combination therapy

  2. BP lowering Drug Efficacy - Monotherapy Law MR, et al. BMJ 2003

  3. The importance of combination therapy • Van Swieten PA. ESC Scientific Newsletter 2003; 4: 1–2. • Chobanian AV, et al. JAMA 2003; 289(19): 2560–2572. About half of patients with hypertension require two or more drugs for adequate hypertensive control1 The importance of combination therapy is reflected in current guidance for the management of hypertension1,2 Combination therapy is especially important in the management of patients with diabetes and hypertension; two or more drugs are often needed to obtain the target blood pressure of 130/80 mm Hg2 The initiation of combination therapy may increase the chance of achieving blood pressure control in a timely fashion2

  4. Use of combination therapy in clinical practice • McInnes GT. J HypertensSuppl 2005; 23: S3–S8. • Dahlöf B. Am J Hypertens 2004; 17: S248. Rigorous blood pressure control with a combination of agents is still rare in clinical practice1 Combination therapy, using low doses of two or more agents, increases blood pressure control and improves tolerability, compared with monotherapy2 Prescribing habits must change to prevent the continued rise of cardiovascular complications1

  5. Effect of two drugs in combination Law MR, et al. BMJ 2003

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