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Chapter 8: Sampling, Standardization & Calibration

Chapter 8: Sampling, Standardization & Calibration. CHE 321: Quantitative Chemical Analysis Dr. Jerome Williams, Ph.D. Saint Leo University. Overview. Standardization & Calibration Sensitivity & Detection Limits. Standardization & Calibration.

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Chapter 8: Sampling, Standardization & Calibration

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  1. Chapter 8: Sampling, Standardization & Calibration CHE 321: Quantitative Chemical Analysis Dr. Jerome Williams, Ph.D. Saint Leo University

  2. Overview • Standardization & Calibration • Sensitivity & Detection Limits

  3. Standardization & Calibration • Calibration determines relationship between analyte response & analyte concentration. • Accomplished using chemical standards.

  4. Standardization & Calibration • Comparison with Standards • Direct comparison (Colorimeters & Titrations) • External Standard Calibration (Least Squares Method)

  5. Figure 8-9 p172

  6. Figure 8-10 p172

  7. Table 8-1 p175

  8. Table 8-2 p177

  9. Table 8-3 p178

  10. Fig 8-9, p.195

  11. Standardization & Calibration • Errors in External Standard Calibration • Blanks are used to correct for many calibration errors. • Ideal blank contains everything except the analyte. • Solvent blank or reagent blank more practical.

  12. Standardization & Calibration • Minimizing Errors in Analytical Procedures • Multivariate Calibration • Saturation, Matrix Modification, & Masking • Internal Standard Methods • Standard Addition Methods

  13. Sensitivity & Detection Limits • Be familiar with the following terms • Analytical & Calibration Sensitivity • Detection Limit • Linear Dynamic Range • Control Chart (including UCL, LCL) • Statistical Control • Validation & GLP

  14. Figure 8-14 p187

  15. Figure 8-15 p189

  16. p189

  17. p189

  18. Figure 8-16 p190

  19. Suggested Problems • HW Set 7: 8.1, 8.2, 8.3, 8.17, 8.26

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