1 / 17

Circadian rhythms and aging

Circadian rhythms and aging . Julia Tong RE|NOUS March 03, 2014 General Meeting III . Outline. What is circadian rhythms (CR)? How does CR pertain to aging? How does CR affect AD? . Circadian Rhythms . Body go through cycles each day to maintain homeostasis.

ollie
Download Presentation

Circadian rhythms and aging

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Circadian rhythms and aging Julia Tong RE|NOUS March 03, 2014 General Meeting III

  2. Outline • What is circadian rhythms (CR)? • How does CR pertain to aging? • How does CR affect AD?

  3. Circadian Rhythms • Body go through cycles each day to maintain homeostasis. • Every cell in your body has a rhythm (internal clock) and the output oscillates according to the environment. • Examples: • Blood pressure • Melatonin levels • Liver enzymes • Body temperature

  4. Circadian Rhythms II • Think of bodily functions and secretions are clocks • SCN is the central clock • It is the site of the biological clock • Without it, the body is arrhythmic • Animal dies

  5. SCN is critical to Circadian Rhythms Lehman et al. 1987

  6. Central Clock Genes

  7. Circadian Rhythms and Aging • Aging changes the human circadian behavior • Older humans/animals circadian activity cycle shortens with age. • Think about your own circadian (sleep/wake) cycle! • Numerous studies have shown CR interconnected with longevity and age related changes in rhythms. • No clear mechanistic or molecular factors identified yet.

  8. Looking at SIRT1 role in central circadian control of physiology and behavior

  9. Results

  10. Jetlag

  11. SIRT1 Function

  12. Paper’s Conclusion • SIRT1 regulate central circadian control to determine period, acitivty level, and adjust to reentrainment. • SIRT1 directly activates Bmal1 in SCN • Increasing expression of other clock genes • Aged mice have low SIRT1 and BMAL1 • Inability to adjust to abrupt light adaptation • Overexpressing brain SIRT1 are partially protected • Reversitol • Low fat diet

  13. CR and Alzheimer’s Disease • AD pts. have disrupted CR • Sundowning: agitated during evening • Never get a complete night sleep, issues with sleep/wake cycle. • Sleep disturbances have devastating effects that leaves pts. Institutionalize. • Studies show that AD pts have disturbances in CR and sundowning is related to phase delay of body temperature

  14. Slow aging with a good clock • Treat age related diseases by enhancing Circadian Function. • SIRT1 to brain • Other drugs along pathway • Treatment for AD patients, ease sundowning • Adjust patients to the Light/dark cycle • Understand patient’s CR • Sync them to environment • Bright light during morning • Melatonin at night

More Related