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Cellular Physiology of Secretion and Absorption

Cellular Physiology of Secretion and Absorption. Jack L. Leonard 2004. Johnson Chap. 34-35. Daily Secretion of Digestive Fluids. Johnson Chap. 34-35. Basic Secretory Mechanisms. Outside. Inside. (Gut lumen). (interstitial space). Na. Na. P. K. Na. K. K. Basolateral membrane.

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Cellular Physiology of Secretion and Absorption

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  1. Cellular Physiology of Secretion and Absorption Jack L. Leonard 2004 Johnson Chap. 34-35

  2. Daily Secretion of Digestive Fluids Johnson Chap. 34-35

  3. Basic Secretory Mechanisms Outside Inside (Gut lumen) (interstitial space) Na Na P K Na K K Basolateral membrane Apical membrane Johnson Chap. 34-35 Redrawn from Acta Physiologica Scand. 42:298, 1958

  4. Outside Na+ Inside (interstitial space) (Gut lumen) Channels K+ Cl- P Na+ coupled organic Na+ glucose Cl- Antiporter HCO3- Na+ Basolateral Apical Symporter K+ 2Cl- Apical Surface Apical Membrane Johnson Chap. 34-35 Johnson Chap. 34-35

  5. Outside Inside (interstitial space) (Gut lumen) P H+ Antiporter Na+ Na+ Basolateral Apical Symporter K+ 2Cl- Basolateral Membrane Basolateral Surface Na+ Active Transporter ATP K+ Johnson Chap. 34-35 Johnson Chap. 34-35 Johnson Chap. 34-35

  6. Na Pump Transport Rate 40 30 Transport Rate 20 10 5 10 15 20 Na+ (mM) (Intracellular) Johnson Chap. 34-35

  7. Na+ Cl- K+ Na+ Na+ Na+ K+ K+ K+ K+ Salt Secretion Salt Absorption interstitial space interstitial space Gut lumen Gut lumen Cl- Cl- Na+ Johnson Chap. 34-35

  8. Na 140 120 Cl 100 80 Ion concentration (mM) 60 40 HCO3 20 K 0 Salivary Duct Cell Saliva Plasma 100 Na 80 60 Ion concentration (mM) 40 HCO3 Cl 20 K 0 4 1 2 3 Flow (ml/min) Johnson Chap. 34-35

  9. K+ Cl- Na+ Na K+ Na Serosal surface ATP Na+ K+ Cl- K+ Lumen Johnson Chap. 34-35 Salivary Acinar Cell stimuli Secretion of Na+, K+, and Cl-

  10. Salivary Duct Cell Serosal surface K+ Na+ ATP Na+ K+ H+ CO2 CO2 H2CO3 HCO3- Na+ K+ Cl- HCO3- Na+ K+ Cl- Lumen Cl- Na+ Johnson Chap. 34-35 Johnson Chap. 34-35

  11. Na 140 120 Cl 100 80 Ion concentration (mM) 60 40 HCO3 20 K 0 Salivary Duct Cell Saliva Plasma 100 Na 80 60 Ion concentration (mM) 40 HCO3 Cl 20 K 0 4 1 2 3 Flow (ml/min) Johnson Chap. 34-35

  12. 340 pH Osmolality Osm 300 260 8.2 pH 7.8 7.4 Pancreatic Secretion 160 Na+ HCO3- 120 Ion Concentration (mM) 80 40 Cl- K+ 0 0 300 500 100 Secretion rate (ml/hr) Johnson Chap. 34-35

  13. K+ ATP Na+ Na+ Intestinal Absorbing Cell Serosal surface K+ Na+ ATP K+ HCO3- Cl Cl Cl- K+ Cl- Na+ Na+ glucose Lumen Johnson Chap. 34-35

  14. K+ ATP Na+ Intestinal Secretory Cell Serosal surface Cl- Na+ Na K+ Na K+ Na+ stimuli ATP K+ Cl- Cl- Lumen Johnson Chap. 34-35

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