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Objectives. Circulation of the brainPathways affected in Locked-in SyndromeClinical features of Locked-in SyndromeLong-term implications of Locked-in Syndrome. Background. 1845: Dumas' The Count of Monte Cristo describes the syndrome1966: Plum and Posner1) the presence of sustained eye opening 2) preserved awareness of the environment3) aphonia or hypophonia 4) quadriplegia or quadriparesis.
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