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Introduction General Applications of BioMaterials ...

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Introduction General Applications of BioMaterials ...

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    1. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 1 Introduction & General Applications of BioMaterials – Lecture Slide Set 1 Dr. Anthony Brennan University of Florida Tel: 352.392.6281 Email: abrennan@mse.ufl.edu

    2. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 2 Guidelines Approach Lecture Demonstrations Interactive Designed for questions Verbal Written Content Variable based upon class Adjustable based upon requests

    3. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 3 Lecture 1 - Introduction, Fundamentals, Nomenclature, applications of biomaterials Learning Objectives: Course overview Text: ..\..\ema6580\EMA6580-Sci-of-Biomaterials-ABET-Syllabus-Spring-2011.pdf Grading Schedule: ..\..\ema6580\EMA6580-Sci-of-Biomaterials-Lecture-Schedule-Spring-2011.pdf Research Proposal NIH Guidelines: ..\..\ema6580\Research_Proposal_Guidelines.pdf Biomaterials Areas of Research - MSE Applications/Devices Issues Time Dependent Life Cycle

    4. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 4 Material Properties Chemical Physical Electronic Magnetic Optical Bioactivity

    5. Biomaterials “A biomaterial is a nonviable material used in a medical device, intended to interact with biological systems.” (Attributed to Williams 1987, cited in Biomaterials Science, ed Ratner, Hoffman, Schoen and Lemons, John Wiley & Sons, Inc., p2) “Biocompatibililty is the ability of a material to perform with an appropriate host response in a specific application” (Attributed to Williams 1987, cited in Biomaterials Science, ed Ratner, Hoffman, Schoen and Lemons, John Wiley & Sons, Inc., p2) Issues to consider: Viability Temporal Placement EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 5

    6. Biomaterials Research Materials Science and Engineering University of Florida Alzheimers/Fe Research (Batich) 6 EMA 6580 Science of Biomaterials - University of Florida Copyright 2009

    7. Applications of Biomaterials (Medical) EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 7

    8. Medical Health Care in US Cardiovascular Diseases and Strokes $475 Billion per year (2009) American Heart Association $508 Billion – including health care and lost productivity CDC Report Coronary Heart Disease $120.6 Billion per year (2008) The Silverbook Report CVD Mortality 958,775 lives per year (1/33 sec) Florida’s Taxable Resources $953.9 Billion (2007) US Treasury Report NIH Budget for NHLBI (2008) $29.2 Billion $9.8 Million (Grants ONLY) Source: American Heart Association Web page Federal Transportation Funding $67 Billion (2008)

    9. Issues to Consider Ethics “Do no harm” Function Life Cycle Toxicology Patient Compliance Education Analyses Chemical Mechanical Electronic Biologic Manufacturing Clinical Regulatory EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 9

    10. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 10 Importance of Chemistry Protein Tertiary Structure Conformational Structure

    11. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 11 Importance of Chemistry Balance of Three Energies Intermolecular Intramolecular Thermal (kT) Structures Linear Branched

    12. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 12 Characteristic Atomic Bonds

    13. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 13 Summary Biomaterials are designed to function in specific applications for limited time to enhance or replace tissues. Biomaterials design requires a team approach. Biomaterials require constant improvements as knowledge increases. Health Care Costs Growth outpace GD.P Ethics are the key to successful development and implementation of biomaterials.

    14. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 14 Additional References “Biomaterials Science – An Introduction to Materials in Medicine,” Ed. B. D. Ratner, A. S. Hoffman, F. J. Schoen, and J. E. Lemons, Academic Press, 1996, ISBN: 0-12-582460-2 Web resources listed in lecture

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