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Schmidt Lab Biomaterials Applications

Schmidt Lab Biomaterials Applications. Spinal Cord Repair Strategies (Zin). Soft Tissue Scaffolds (Richelle). Surgical Meshes (Sarah). Sources of Peripheral Nerve Injury. Cancer. Accidents. Congenital Defects. Photocrosslinked Hyaluronic Acid (GMHA). High Swelling HA Hydrogels.

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Schmidt Lab Biomaterials Applications

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  1. Schmidt Lab Biomaterials Applications Spinal Cord Repair Strategies (Zin) Soft Tissue Scaffolds (Richelle) Surgical Meshes (Sarah)

  2. Sources of Peripheral Nerve Injury Cancer Accidents Congenital Defects

  3. Photocrosslinked Hyaluronic Acid(GMHA) High Swelling HA Hydrogels Low Swelling HA Films Unswollen Saline Swollen Water Swollen Modulate: -Swelling -Degradation -Mechanical Properties

  4. 25 mm 12 mm Role of Physical vs. Chemical Cues Microchannels vs. Laminin Gomez, Chen, Schmidt (2007). J. R. Soc Interface. 4(13): 223-233. Physical cues are preferred over chemical cues for axon initiation (polarization) 70 %  Physical Cues (microchannels) 30 %  Chemical Cues (NGF or Laminin)

  5. In Situ Crystallization: Dendritic Pores In Situ Crystallization: Dendritic Pores • Simple, inexpensive • No specialized equipment • No specialized skills • No organic solvents

  6. Fibrillar, Porous Microstructure AFM SEM

  7. Cell Guidance Zawko, Schmidt. (in press) Acta Biomaterialia.

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