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Synthesis of Cationic Nanogels Through Microemulsion Polymerization. Tamona Williams SPGRE 2001 Research University of North Carolina Department of Chemistry. Microemulsion.
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Synthesis of Cationic Nanogels Through Microemulsion Polymerization Tamona Williams SPGRE 2001 Research University of North Carolina Department of Chemistry
Microemulsion A water-in-oil microemulsion is an optically transparent mixture oil, water,and surfactant. Water droplets are in a continuous oil phase stabilized by surfactant. Continuous Oil Phase Surfactant Molecules Water Droplets
Microscopic Appearance Microemulsion Polymerization Surfactant and oil phase removed Initiator added in oil phase Isolation of Particles in H2O Microemulsion Polymerization
Structure of Monomers Used in Microemulsion Polymerization PEGdiacrylate 2-Hydroxylethylacrylate 2-Acryloxyethyltrimethylammonium chloride
Characterization of Nanogels Proton NMR Transmission Electron Microscopy Dynamic Light Scattering
TEM Images of Cationic Nanogels: 0% Charged Monomer 12% Charged Monomer 6% Charged Monomer 66K Magnification on Copper-Formvar Grid and Stained with PTA
Dynamic Light Scattering Data Diameter of Nanogels by Dynamic Light Scattering
Formulation of Microemulsions with Charged Monomer Objective: To form microemulsion with increased amount of 2-acryloxyethyltrimethylammonium chloride Increasing Monomer Concentration
Conclusions • Cationic nanogels were formed with a maximum of 12% charged monomer. • Decreasing the amount of surfactant allows the formulation of microemulsions at high percentages of charged monomer. • Further analysis of how surfactant controls the amount of charged monomer that will formulate a microemulsion, may aid in developing nanogels with more charge.
Acknowledgements SPGRE – National Science Foundation Dr. Joeseph DeSimone Dr. Michael Rubenstein Karen Erford