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Life Science for Health and Innovation Time to Transform Sten G E Lindahl Karolinska Institutet Karolinska University

Life Science for Health and Innovation Time to Transform Sten G E Lindahl Karolinska Institutet Karolinska University Hospital Stockholm, Sweden. Fosbury Flop. Western Roll. Scissors. Incremental or Quantum Leaps ?. Olympic Gold Medal Winners in High Jump. 2.6 2.4 2.2 2 1.8

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Life Science for Health and Innovation Time to Transform Sten G E Lindahl Karolinska Institutet Karolinska University

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  1. Life Science for Health and Innovation Time to Transform Sten G E Lindahl Karolinska Institutet Karolinska University Hospital Stockholm, Sweden

  2. Fosbury Flop Western Roll Scissors Incremental or Quantum Leaps? Olympic Gold Medal Winners in High Jump 2.6 2.4 2.2 2 1.8 1.6 Straddle Quantum Leap Incremental 1900 1920 1940 1960 1980 William F. Achtmeyer Center for Global Leadership - Tuck School of Business at Dartmouth Source: Pascale

  3. Molecular Biology towards Molecular and Regenerative Medicine Quantum Leap Incremental 195019651980 1995 2010

  4. Pathogeneticmechanisms and Phenotypes GeneticInitiators Individualized Preventive Prognostic

  5. Research Knowledge Triangle Growth & Jobs Innovation Education Creativesector

  6. Challenges Clusters Systems Collaborative research Joint Technology Initiatives such as medicines,nanoelectronicsaso International cooperation • More integration thanbefore • Universities • Long term research • Frontier research • Capacitybuilding • - infrastructure Partnerships Univ - Univ Hosp & Society/Industry Intellectual Property & Biotechnology

  7. Outline Life Science & Modern Health Care Scientificquestions Public and Private Transforming

  8. Life Science & Modern Health Care

  9. Medical Research Basic Medical Science ClinicalScience/Clinical testing Implementation in Clinical Practice

  10. Natural Sciences Physics Mathematics Biology Chemistry Technology Medicine

  11. Current clinical subjects Entireity or Fragmentation?

  12. Brilliant individuals Brilliant systems

  13. Advantages – Enhanced Potentials Create an Internal Market for Research Research betterfunded DiminishFragmentation

  14. www.toolsofscience.eu - Chamber of Commerce, Milano, Italien - One Nucleus, London-Cambridge, Storbritannien - Heidelberg Technology Park, Heidelberg, Tyskland - INNOVA, Debrecen, Ungern - Medicen, Paris, Frankrike - Matimop, Tel Aviv, Israel - Alsace Biovalley, Alsace, Frankrike - Bioindustry Park SilvanoFumero, bioPmed innovation cluster, Torino, Italien - Barcelona Science Park, Barcelona, Spanien - BioWin, Vallonien, Belgien - Medicon Valley Alliance, Medicon Valley, Danmark-Sverige - BioM Biotech Cluster Development, Munchen, Tyskland - Stockholm Science City, Stockholm, Sverige www.stockholm-life.se

  15. Searching CommonDenominators

  16. Future Medicine based on Science and Development WouldPathogeneticmechanisms be the logicaldenominator? If so, are todaysclinicaldepartmentsbased on pathogeneticmechanisms? If not, whatthen??

  17. Infection-Inflammation-Immunology Clusters Cardiovascular-Diabetes-Kidney Cancer-Hematology Infection-Inflammation-Immunology Neuroscience-Psychiatry Regenerative/ReparativeMedicine Reproduction& DevelopmentalMedicine Endocrinology & Metabolism Cardiovascular-Diabetes-Kidney Cancer-Hematology Infection-Inflammation-Immunology Neuroscience-Psychiatry Regenerative/ReparativeMedicine Reproduction& DevelopmentalMedicine Endocrinology & Metabolism

  18. Will a Thriving High performance organisation be Vertical or Horizontal? or Both ??

  19. The ScientificQuestion Einsteins challenge (but not Bohrs)

  20. ß3 ß3 Proton gradient acrossMitochondrialMembranes NE AC cAMP PK lipid droplet HSL acyl-CoA FFA proton circuit acyl-carn H+ respiratory chain ß-oxidation CAC acyl-CoA thermogenin ATP mitochondrial membrane cell membrane

  21. 1 nanometer, nm, is 1 billionth of a meter 1 atom = 0.1nm; 1 turn of the DNA-spiral is 3.4 nm Biomechanics from macro- to nano-scale Whenwillwe be able to image/visualize a turn of the spiral ? Nanotechnology 2015 2 million jobs ;10 billion €

  22. Public and Private

  23. The Boston Globe

  24. Trust in Research Weakening trust for researchers in western regions (around 50%). It may be comforting that the figure for Medical researchers was 77%. A leadingtraditionaluniversitycan no longerstate: ”?? is not obliged to compete. There are no challengersperpetuallyreadyto depose ??from itspre-eminent position”

  25. Universities are beingchallenged There is a Competition Ranking and Metrics To Measure and Be Measured To Change – ButHow?

  26. That is bad for academies and the societiesweseek to serve. Henry Rosovsky, The University, W W Norton and Company, 1991 The University as a Marketplace A University cannot be run by cost accountants or Act as a commercial enterprise responding only to changing markets.

  27. Competinglogics Different levels of Partnerships Managerialism & Professionalism Knowledge transfer Academia & Commercialism

  28. A Partnership is a Partnership is a Partnership Academic Medical Centers (mergers are high risk) Universities(LoI or MoU) Public and Private (open innovation) Departments Research groups Individuals

  29. Competinglogics Different levels of Partnerships Managerialism & Professionalism

  30. Competinglogics Different levels of Partnerships Managerialism & Professionalism Knowledge transfer Academia & Commercialism

  31. Academic Health Centers Society Knowledge Transfer Economics Research Patents Publications People Contracts Networking Start-ups Knowledge triangle Growth & Jobs Health Care Education Investments Innovation

  32. Academy Commercialism Hiring Using money Teaching Earning money Commercialism Academy Knowledge Transfer New Knowledge Talents

  33. Transforming Doubt, Develop and Change

  34. Transforming Challenges in the North Neurodegenerative diseases Cancer Cardio-Vascular and Hypertension Diabetets The MetabolicSyndrome Stress and Psychiatricconditions Challenges in the South: Nutrition and Poverty Gastrointestinaldiseases and Diarrea HIV/AIDS Malaria-Polio-Tuberculosis Familyplanning Tobacco and Nicotin The Art of MaintainingWellness

  35. Leadership Measurements Change

  36. The philosophical doubt Descartes and Spinoza Development: the driving force Comte and Spencer Darwin and Haeckel

  37. To Measure & To Be Measured Own Other High Performance

  38. To Measure

  39. To be Measured Siegmund Freud to Stefan Zweig: "Up to now I haveconsideredsurrealists………..asincurablenutcases. The youngSpaniard, however,……. has mademereconsider….. In fact, it would be veryinteresting to investigate the way in whichsuch a painting has beencomposed." Metamorphosis of Narcissus

  40. Change The philosophical doubt Descartes and Spinoza Development: the driving force Comte and Spencer Darwin and Haeckel Innovation/Development/Change The enemy of Status Quo

  41. Summing up Creativity Fantasy Public and Private Transforming Scientificquestions Life Sci & Modern Health Care

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