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Research at Karolinska Institutet

Research at Karolinska Institutet. 2010. Karolinska Institutet A leading medical university. Dedicated to improving people’s health through research and higher education. The largest centre for medical education and research in Sweden. Research – from molecule to patient. 22 departments

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Research at Karolinska Institutet

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  1. Research at Karolinska Institutet 2010

  2. Karolinska InstitutetA leading medical university Dedicated to improving people’s health through research and higher education

  3. The largest centre for medical education and research in Sweden

  4. Research– from molecule to patient • 22 departments • 600 research groups • 1,500 researchers/teachers including 328 professors • 2,000 doctoral students

  5. Traditions and innovations A few examples of our notable research achievements: • SR – sedimentation rate • Purification of insulin and heparin • Sulphasalazin • Antibodies from plasma cells • Seldinger catheter • Pacemaker • Gamma knife • Growth hormones Nanna Svartz, the first female professor at Karolinska Institutet 1937-1957, developed one of the first anti-inflammatory drugs for rheumatoid arthritis

  6. Swedish Nobel Prize Laureates in Physiology or Medicine – 5 of 8 are from Karolinska Institutet: • 1955 Hugo Theorell, - the oxidation enzymes • 1967 Ragnar Granit, - the visual processes • 1970 Ulf von Euler, - noradrenaline • 1982 Sune Bergström & Bengt Samuelsson, - prostaglandins

  7. Scientific publications 2009 • About 3,000 original articles and 1,000 other publications were written by researchers at Karolinska Institutet 2009 • 60 per cent have co-authors outside Sweden • Cited approx 50 per cent more often than the global average (2008)

  8. Research funding accounts for 83 per cent of Karolinska Institutet’s total income

  9. Research revenue 2009total SEK: 4,057 million (2008: 3,586 million)

  10. Februari 2010 Research funding

  11. Februari 2010 Revenue from EU and USA

  12. Board of Research Strategy Research funding and recruitment Research networks Centres of excellence Core facilities Junior faculty Biosafety and ethics Veterinary unit 22 Departments Research Doctoral education Organisation

  13. The Stockholms Academic Healthcare System

  14. Fields of research • Cancer • Circulation and respiration • Endocrinology and metabolism • Infection • Inflammation and immunology • Neuroscience • Public and international health • Reproduction, growth and development • Tissue and motion

  15. Nationally funded Centres of Excellence (Linné) • Centre of Excellence in Developmental Biology for Regenerative Medicine • STARGET – a cancer research network • Center for Research on Inflammation and Cadiovascular Disease, CERIC • The Human Regenerative Map • Linné Centre for Prevention of Breast and Prostate Cancer

  16. Other nationally funded Centres of Excellence • Aging Research Centre • Centre for Allergy Research • Centre for Health Equity Studies • Centre for Infectious Medicine • Stockholm Brain Institute • Strategic Research Centre for Studies of Integrative Recognition in the Immune System • Structural Genomics Consortium • Swedish Brain Power

  17. Core facilities in many areas • KI Biobank • Registers • Bioinformatics and biostatistics • Clinical trial centres • Experimental models • Expression analysis • Genomics • Proteomics • Visualisation techniques

  18. Strong Research Potential Basic Research and Clinical Research Come Together Translational Research

  19. Research profileEpidemiology • KI Biobank - core facility for all research • contains samples of tissue, blood, serum, plasma, DNA and other biological specimens • Twin Registry – the largest in the world • invaluable resource when correlating between genes, lifestyle and environment • Medical informatics • strong competences in health informatics and biostatistics

  20. Research profileCellterapy – from stem cell to therapy Advanced stem cell research • Strong clinical expertise in cell therapy and transplantation medicine • International leadership in developmental biology • Embryonic stem cell lines Research focus on • Parkinson’s disease • Spinal cord injuries • Diabetes • Musculature disease • Tissue impairment after cardiac infarction

  21. Research profileNeuroscience • Approx. 20 per cent of all research at Karolinska Institutet is in neuroscience Three world-leading research centres • Spinal Cord Research Centre • Gather about 10 research groups • Stockholm Brain Institute • Interdisciplinary research in neuroscience, psychology and computer science • Alzheimer Centre • Translational research in brain aging, dementia and Alzheimer's disease

  22. Research profileInfectious diseases and immunology • Leading researchers in virology, bacteriology, parasitology and immunology • Neighbouring the largest infection clinic in Sweden • Advanced laboratory facilities • Strong international collaborations Research focus • Global infections – HIV, malaria, tuberculosis, pneumonia • Basic immunology, inflammation and infection medicine

  23. Research profileCancer • Basic research in the emergence/origin and development of cancer • Cancer epidemiology • Therapy research, e.g. hormone, immune, and gene therapy • Optimizing of radio therapy • Clinical trials • Quality of life

  24. Research profileInflammatory diseases and allergy • Reumatoid arthritis • Multipel sclerosis • Nerve and muscle inflammation • Immune defects • Autoimmunity • Allergies and eczema • Asthma and COPD • Atherosclerosis

  25. Research profileMetabolic diseases • Obesity • Advanced research in adult and child obesity • Close clinical collaboration • Diabetes • Basic research in diabetes research • Treatment research • Stem cell research • Cardiovascular research • Inflammatory factors • Cholesterol metabolism • Gender aspects in diagnosis and care

  26. Research profileAging research • Aging Research Centre • Research from a medical, psychological and socioeconomic perspective • Dementia • Early diagnosis and treatment of cognitive impairment • Alzheimer Centre • Swedish Brain Power • A national research consortium in neurodegenerative diseases

  27. Research profileGlobal health Partnerships on all continents Research focus on poverty and health Vaccines – HIV, malaria, tuberculosis • Reproductive medicine • Occupational medicine • Psychiatry • Geriatrics • Humanitarian disaster assistance

  28. Research collaborations • Health care sector • Swedish and foreign universities • Industrial partners • International agreements with organizations in Europe, North America, Africa and Asia • Offices in China and Singapore

  29. Karolinska Institutet Innovation- from brains to business • Promotes the results of biomedical research to be developed into new products and applications • Provides the means for researchers to develop their research results commercially • Offer project management, funding for patent protection, legal advice and business development • Allows researchers access to an extensive network of contacts within the international pharmaceutical industry

  30. Karolinska Institutet Innovation • Reviewed more that 1 100 academic inventions • More than 40 companies formed since 1996 • 35 license agreements concluded • The system’s portfolio companies own about 100 patents • 30 development project are in its portfolio pipeline

  31. More information: ki.se 09/1

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