Muscular Dystrophy

1. Muscular Dystrophy Evaluation of Mamsagni Rasayana [MGR] in 55 Patients of DMD, BMD & LGMD Mukesh Jain, AMDS India The Ayush Samiti Bhilai CG

4. Muscular Dystrophy • Incurable Genetic disease • The dysfunction of Vata & Dhatvagnis is the main pathology. Muscle degeneration due to progressive diminishing of Mamsagni along with aggravation of Vata element. • Symptoms & Signs: # Large calf muscles • # Walking on the toes • # Using the hands to rise from a sitting position, called Gower's sign • # Progressive muscle deterioration, starting with the muscles nearest the hips • # Curvature of the spine # Enlargement of the heart muscle • # intellectual impairment # Breathing Difficulty.

5. Muscular Dystrophy

7. Mamsagat Vata Vyadhi

9. Treatment, Help & Monitoring • The major goal of early treatment is to keep the ability to walk as long as possible. • Pawan Muktasana, Stretching exercises and using braces at night help avoid the tightening of tendons. • Surgery can be used to release tight tendons. • Mamsagni Rasayana is promising molecule. It is an ayurvedic dietary supplement and is safe and superior than Prednisone for long term management of muscular dystrophies.

10. Ayurvedic Treatment • Panch Karma & Rasayana treatments have shown promising protective effects on NMD. • These therapies and remedies help in the regeneration of dhatus because they are capable to balance the Doshas and Agnis. • TMP Swedana procedure is effective to stabilize Vata dominant Sarcolemmal membrane defect.

11. AMDS India Study involving Mamsagni Rasayana along with TMP & Yogic Support yielded mixed results in 55 boys of DMD, BMD & LGMD Care through Research Clinic Bhilai

12. . Over 100 cases of Muscular dystrophies were enrolled at Panch Karma Clinic of Central Medical Institute, Bhilai & treated during March 1999 & Sep 2004. 28 DMD , 19 BMD 8 LMGD boys All the Dystrophy boys were subjected to 2 weeks Panch karma procedures before administration of oral Mamsagni Rasayana along with Yogic support for 6 months.

13. Observation & Results: • It was observed that degeneration of muscle fibers were arrested after 6 weeks of administration of Mamsagni Rasayana. This was presumed on the basis of reduced CK level in blood and functional improvement such as • (i) Weight loss, (ii) Decrease in walking difficulty and (iii) Decrease in the severity of contractures and scoliosis. However DMD boys have shown very slow progress.

14. RESULT ANALYSIS : DMD(BARTHEL -SANJEEVAN SCALE) • MARKED RELIEF 42% • MODERATE 21% • MILD RELIEF 36.8%

15. RESULT ANALYSIS

16. Average Observations • Improvement in Functional Ability visible after 6 weeks of Administration of MGR • Presumption : Reduced CPK level, weight loss, Decrease in Walking difficulty. • Decrease in the Severity of Contractures and Scoliosis.

17. Average Decrement in 24 Weeks 45% -2.8 Kg. -2800 (IU) 10% CONTRACTURE BLOOD CK SEVERITY WT LOSS

18. Quality of Life Improvement 90% 60% 40% SELF CONFIDENCE ENDURANCE FUNCTIONAL

19. A Case Of DMD PATIENT BEFORE TREATMENT PATIENT AFTER TREATMENT

20. EFFECT OF TMP IN DMD BEFORE REATMENT AFTER TREATMENT

21. Effect of Mamsagni Rasayana BEFORE TREATMENT AFTER TREATMENT

22. Functional Improvement in a DMD BEFORE TREATMENT AFTER 12 WEEKS

23. Improvement in DMD Boy BEFORE TREATMENT AFTER TREATMENT