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Project Office Update November 7, 2013

Project Office Update November 7, 2013 . Jacques E Rossouw. Renewal . Renewal proposal approved for further development (i.e., developing Acquisition Plan) Budget subject to availability of funds --sequester, etc. Initial approval for 3 year period

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Project Office Update November 7, 2013

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  1. Project Office Update November 7, 2013 Jacques E Rossouw

  2. Renewal Renewal proposal approved for further development (i.e., developing Acquisition Plan) Budget subject to availability of funds --sequester, etc. Initial approval for 3 year period --period could be adjusted depending on outcome of BEE/Council WG

  3. Unique Strengths of WHI By 2050 number of US women aged >65 will have doubled to 49 million. CVD deaths account for 36% of total deaths in older women By 2016 WHI projects to have 85,000 participants with mean age 83 (range 66-102), N=52K or 58% age >80. In MRC project 21K women (including 5.8K AA, 2.2K Hispanic) by 2016

  4. Current and Future Mission • Expand knowledge about the determinants of CVD in older women (and conversely determinants of successful aging with absence of CVD) • Particular focus on understudied conditions of heart failure, atrial fibrillation, periperal arterial disease, aortic stenosis • Fully utilize the new data and bloods from the LLS subcohort

  5. Current and Future Mission • Expand the study as a scientific resource for the research community • GWAS=32K, ExomeChip=25K, Metabochip=15K • Mentor young investigators • ~150 mentored during current renewal • 2010 Chicago Workshop to date has led to 21 approved manuscript proposals and 5 published papers • Facilitate a new generation of large simple trials • Cocoa and multivitamin (Manson) • Physical Activity (Stefanick/LaCroix) • Vitamin D (Jackson) • Continue research into utility of CMS data

  6. Selected Research Examples • Determine whether race/ethnic differences in CVD risk are explained by SES, risk markers, genomics, life habits, medical coverage, or environmental factors • Determine influence of risk factors (including genomic) and exposures on heart failure (including HF with preserved systolic function), AF, AS, PAD • Create CVD survivor cohort by following up incident events through CMS for recurrence, morbidity/mortality, quality of care, healthcare utilization and expenditures

  7. Selected Research Examples • Integrate gene variants, methylation, expression, regulation, metabolome, and biomarkers in systems biology approach to CVD pathways • Determine influence of baseline LTL on successful aging/absence of CVD and the determinants of attrition in LTL and its association with CVD risk

  8. Some Initial Results: Dissemination and Mentoring2010-2015 • Total ancillary studies = 225 (April, 2013) • Before 2010 52% led by new investigators • After 2010 63% led by new investigators • Publications = 814 (April, 2013) • Before 2010 30% led by new investigators • Since 2010 51% led by new investigators

  9. Conclusions • WHI cohort study • Increasingly productive • Cost-effective • High impact (~2400 cites per year since 2010) • Mentoring and dissemination efforts are showing results • Need more focus on CVD in older women

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