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CTGF modulates Aortic Vascular Smooth Muscle Cell phenotype and regional tissue homeostasis

CTGF modulates Aortic Vascular Smooth Muscle Cell phenotype and regional tissue homeostasis in Bicuspid Aortic Valve-associated Thoracic Aortic Aneurysms.

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CTGF modulates Aortic Vascular Smooth Muscle Cell phenotype and regional tissue homeostasis

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  1. CTGF modulates Aortic Vascular Smooth Muscle Cell phenotype and regional tissue homeostasis in Bicuspid Aortic Valve-associated Thoracic Aortic Aneurysms Emanuela Branchetti PhD1, Karianna R. Milewski MD PhD1, Eric Lai BS1 Rachana Sainger PhD1,Paolo Poggio MS1, Robert C. Gorman, Joseph E. Bavaria MD1 and Giovanni Ferrari PhD1 1Perelman School of Medicine at University of Pennsylvania, Department of Surgery, Division of Cardiovascular Surgery, Philadelphia, PA None of the authors have financial interest in this work.

  2. PATIENTS ENROLLMENT PATIENTS DEMOGRAPHICS

  3. COMPARISON BETWEEN THE AORTIC WALL STRUCTURE OF TAV-C TISSUE AND TAV- AND BAV- AORTOPATHIES.

  4. BAV AND TAV ASCENDING AORTA TISSUES WITH AND WITHOUT ANEURYSM SHOW DIFFERENCES IN THE EXPRESSION OF VSMC MARKERS OF PHENOTYPE

  5. REGIONAL WALL STRESS DISTRIBUTION IN THE ASCENDING AORTA Modified from : Derek P. Nathan,Chun Xu, Arminder S. Jassar, Joseph H. Gorman III,Ron M. Fairman, Joseph E. Bavaria, Robert C. Gorman, Benjamin M. Jackson. Annals of Thoracic Surgery, October 2011.

  6. CTGF IS HIGHLY EXPRESSED IN BAV AND TAV TISSUES WITH ANEURYSM. CTGF UP-REGULATES ECM BIOSYNTHESIS AND IS INVOLVED IN THE PHENOTYPIC CHANGE OF AORTIC VSMC IN VITRO.

  7. VSMC PHENOTYPE AND CTGF EXPRESSION AT CV AND CX SIDE OF ASCENDING AORTA

  8. CTGF INDUCES SYNTHETIC MARKERS OF PHENOTYPE IN VSMC ISOLATED FROM CONTROL AND ANEURISMAL AORTA

  9. CONCLUSION AND FUTURE DIRECTIONS Different stress conditions influence VSMC phenotype in BAV aorta. Characterize CTGF as a regulator of VSMC activation and ECM remodeling could serve as a risk stratification tool for BAV- and TAV-associated aortopathies.

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