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Review of muscle cell structure and phenotype plasticity.

BS277 Biology of Muscle. Review of muscle cell structure and phenotype plasticity. LEARNING OBJECTIVES 1. Review the structure of skeletal muscle. Review of muscle structure. Organism to cell. 6. 8. 10. 4. 5. 2. 6. 7. 1. 10. 3. 8. 10. 7. 11. 9. 15. 18. 4. 12. 16. 10. 17.

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Review of muscle cell structure and phenotype plasticity.

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  1. BS277 Biology of Muscle Review of muscle cell structure and phenotype plasticity. LEARNING OBJECTIVES 1. Review the structure of skeletal muscle.

  2. Review of muscle structure. Organism to cell. 6 8 10 4 5 2 6 7 1 10 3 8 10 7 11 9 15 18 4 12 16 10 17 14 13 8 6

  3. Brachium • Tendon • Skeletal muscle / biceps • Epimysium • Blood vessels and nerves • Perimysium • Muscle fascicle • Muscle fibre / myocyte/muscle cell • Blood vessels • Endomysium • Capillary • Sarcolemma • Sarcoplasm • Nucleus • Mitochondria • Nerve • Satellite cell

  4. Overview of Muscle Development.

  5. Review of muscle structure. Cell to organelle. 2 1 3 2 4 6 7 1 1 4 11 10 9 5 8

  6. Sarcolemma • Sarcoplasm • Nucleus • Myofibril • Sarcoplasmic reticulum • Terminal cisterna • Mitochondrion • T-tubule • Triad • Thick myofilament • Thin myofilament

  7. Review of muscle structure. Cell to organelle.

  8. Review of muscle structure. Myofibril banding pattern. I band A band Z line H zone Titin Thin myofilament Thick myofilament M line Zone of overlap Sarcomere

  9. Review of muscle structure. Myofibril banding pattern.

  10. The molecular basis of the sarcomere banding pattern Sarcomere Thin myofilament Thick myofilament α-actinin Titin Titin

  11. The molecular basis of myofilament structure

  12. The molecular basis of myofilament structure

  13. Sliding filaments and muscle contraction

  14. Overview of the regulation of muscle contraction

  15. The active state. Initiation of cross bridge cycling.

  16. The cross bridge cycle. Step 1.

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