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Exploring Sex-Linked Inheritance in Pedigree Analysis

Dive into the world of sex-linked inheritance and pedigree analysis in biology. Understand traits like hemophilia and colorblindness, and learn to interpret pedigrees to uncover genetic patterns. Collaboration and individual exploration await in this engaging lab activity.

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Exploring Sex-Linked Inheritance in Pedigree Analysis

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  1. Hand in Interpreting Information in a Pedigree W.S. before the bell rings please (not 3A) Chapter 8 – Beyond Mendel Sex-linked inheritance Pedigree lab "Attitude is a little thing that can make all the difference." Sir Winston Churchill To review learning pedigree and try our hand a sex-linked pedigree analysis. Title: Biology 2/8/07 Class Topics Objectives: Wednesday, January 1, 20209:14 PM

  2. Class Assignments What By When • Read 177-182 2/8/07 • W.S. Interpreting Information in a Pedigree 2/8/07 • Not 3A • Lab – A Human Pedigree 2/8/07 • W.S. Interpreting Information in a Pedigree (3A) 2/12/07 • W.S. 8.2 (DR/Color Blind/Gene Spy) 2/12/07 • Due this class period • Due next class period • Due in the future

  3. Grade Sheet 2A – p. 157 (5 pts.)

  4. Sex-linked inheritance • Some genes are carried on the X chromosome - Sex-linked genes • Fruit flies example • White eyed male with red eyed female = all red eyed offspring • Crossed two of the F1 offspring and ended up with 3:1 ratio - red to white (all white eyed flies were male!!!)

  5. Sex-linked inheritance • Found mostly in males • Males are hemizygous • Cannot hide recessive allele • Cannot be carriers of trait • Females can show trait • Must be homozygous recessive • Can carry trait (heterozygous) • Has nothing to do with hormones • Sex-influenced traits

  6. X-linked Traits(Human) • Hemophilia • Queen Victoria (1819-1901), clotting factors • Red-Green colorblindness • Duchenne Muscular Dystrophy • affects children 3-6 years old • defective protein causes muscles to weaken

  7. Lab - A Human Pedigree • Work in partners (one sheet, two names) • Older answers odd questions • Younger answers even questions • Turn in when done! • Pick up and work on (by yourself) • W.S. 8.2 (DR/Color Blind/Gene Spy)

  8. Sex-linked Punnett Squares • X X x X Y • Cross a hemophiliac carrier with a person without hemophilia X X X Y

  9. Sex-linked questions • What do you know about the parents of a colorblind girl? • What do you know about the father of a hemophilia carrier Sex-linked Inheritance Hemophilia Pedigree Colorblindness

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