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Fig. S1. Weng et al.

Relative ELISA titer (%). Fig. S1. Weng et al. 1b 1a 2a. HCR6 RdRp. H77 RdRp. JFH1RdRp. GST-L245A/I253A. A242C/S244D. A238S/Q248E. J6CF RdRpwt. Protein marker. RMT RdRpwt. Con1 RdRpwt. NN RdRpwt. A242C. S244D.

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Fig. S1. Weng et al.

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  1. Relative ELISA titer (%) Fig. S1. Weng et al.

  2. 1b 1a 2a HCR6 RdRp H77 RdRp JFH1RdRp GST-L245A/I253A A242C/S244D A238S/Q248E J6CF RdRpwt Protein marker RMT RdRpwt Con1 RdRpwt NN RdRpwt A242C S244D T251Q D244S L245A I253A wt wt wt kDa 200 116 97.2 66.4 44.3 29.0 20.1 Fig. S2. Weng et al.

  3. % 100 80 60 Relative polymerase activity 40 20 0 0 2 4 820 Ethanol (%) Fig. S3. Weng et al.

  4. 1b HCR6 2a JFH1 1a H77 wt L245A I253A D244S wt A242C/S244D wt A238S/Q248E + + - + + + + + - + + + + - - + - + + + - + + + + + - + + + + + - + + + + + - + + + + + - + + + + + - + + + RNA RdRp SM Fig. S4. Weng et al.

  5. H1 H2 A B Fig. S5. Weng et al.

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