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Antony van Leeuwenhoek 1632-1723. Helicobacter pylori discovered in 1982 by Barry Marshall and Robin Warren. The Ohio State University Joel H. Saltz, M.D., Ph.D. Umit Catalyurek, Ph.D. Albert de la Chapelle, M.D., Ph.D. Ramana Davuluri, Ph.D. Charis Eng, M.D., Ph.D.
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Helicobacter pyloridiscovered in 1982 by Barry Marshall and Robin Warren
The Ohio State University Joel H. Saltz, M.D., Ph.D. Umit Catalyurek, Ph.D. Albert de la Chapelle, M.D., Ph.D. Ramana Davuluri, Ph.D. Charis Eng, M.D., Ph.D. Tahsin Kurc, Ph.D. Wolfgang Sadee, Ph.D. Mary Ellen Wewers, Ph.D., M.P.H., R.N. Haifeng Wu, M.D. Ohio Supercomputer Center Don Stredney, M.A Al Stutz, M.S. Pete Wycoff, Ph.D. Rescentris Adel Mikhail, Ph.D. Jeffrey Spitzner, Ph.D. Joseph Spitzner, Ph.D. Biomedical Informatics Synthesis Platform
Translate dramatic advances in biology to medical treatments Decrease cost of clinical research Increase effectiveness of treatment Decrease time to cure! Goal
Translate advances in functional genomics and imaging technology to advances in medical practice Leverage leading edge computer science technology Motivate development of new ideas in biomedicine and computer science Translational Research
How to discover what is important? HUGE amounts of information Many types of data Data size Maintaining patient confidentiality Large number of participating institutions Challenges
Atherosclerotic process components Cholesterol metabolism and transport Inflammation Coagulation Drug response Statins Cardiovascular project: Pharmacogenomics of Lipid Lowering Therapies in Coronary Artery Disease Glen Cooke, Heart & Lung Research Institute Joel Saltz, Biomedical Informatics Haifeng Wu, Coagulation Clinics Bo Yuan, Genomics Wolfgang Sadee, Audrey Papp, Julia Pinsonneault, Pharmacology Clay Marsh, Heart & Lung Research Institute Avner Friedman, Biomathematical Sciences Institute