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The Contact Allergen Replacement Database. James A. Yiannias MD Associate Professor of Dermatology Mayo Clinic Scottsdale. Purpose. To facilitate antigen avoidance Database generates list of skin care products free of patient’s known allergens > 1,500 U.S. skin care products.
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The Contact Allergen Replacement Database James A. Yiannias MD Associate Professor of Dermatology Mayo Clinic Scottsdale
Purpose • To facilitate antigen avoidance • Database generates list of skin care products free of patient’s known allergens • > 1,500 U.S. skin care products
Utility of Database • Consider a patient who is patch test sensitive to fragrance mix • Patient has been educated how to avoid fragrance, yet... • Eczema persists sincepatient didn’t realize • Cinnamic alc. & Balsam of Peru= Fragrance • Unscented & fragrance free products don’t assure elimination of fragrance cross-reactors
How CARD Helps… • CARD recognizes cross-reactions & synonyms and • generates a comprehensive list of skin care products free of all fragrance like antigens!
Another eg: Utility of CARD • Patient is imid urea & quat-15sensitive • Allergen avoidance reviewed • Patient’s eczema persists-- Pt didn’t realize that DMDM-Hydantoin should be avoided • Database recognizes cross-reactions & deletes all products containing formaldehyde releasers
Products in Database • Soaps, Shampoos, Conditioners • Moisturizers • Sunscreens • Make-ups • All prescription topicals in PDR • All OTC topicals in OTC PDR
How Products Were Chosen • Hypoallergenic skin care product lines (eg. Aveeno, Almay, many others) • Large companies with widely available products
Database Maintenance • All product formulations are updated continuously • Products with formulas > 1 year are deleted
Database Clinical Usage • In use clinically at Mayo Clinic for 6 years and by American Contact Dermatitis Society Members for more than 3 years • Broad patient and physician acceptance / endorsement