Serotonin level and nutritional behavior of patients with primary insulin resistance

1. Serotonin level and nutritional behavior of patients with primary insulin resistance Irina Kurnikova MD-PhD,Professor of Medicinein Endocrinology,  RUDN-university (Peoples' Friendship University of Russia), Moscow. Tatyana Nikishova, PhD, Associate professor, Maria Grishkina Kazan State Medical Academy of Russia, Kazan,Russia

2. The regulation of nutritional behavior The central part: • hypothalamus (food center) • the appetite center (located in the ventro-lateral divisions of paraventricular nuclei) • the saturation center (in the ventromedial nuclei). • Cortical part of the limbic system (food behavior) • girdle gyrus • hippocampus • intraorbital region Peripheral link: • stomach (ghrelin) • adipocyte (leptin) • pancreas (insulin) • small intestine (cholecystokinin, glucong-like hormone)

3. Stages of violations of carbohydrate metabolism and methods of primary diagnosis

4. The main indicators of the hormonal profile in patients with obesity

5. Criteria for assessing efficacy at the stage of progressive weight gain

6. The purpose of this study To assess the influence of acupuncture on the production of serotonin and the features of the nutritional behavior of patients with primary insulin resistance The patients (42 people) aged 38.4 ± 2.0 years, body mass index (BMI) 32.3 ± 4.2 kg / m2. Two groups of observation were formed: group 1 (20 people) received reflexotherapy using special corporal and auricular points and a hypocaloric diet. group 2 (22 people) - diet. The comparison group - 12 healthy individuals. Serotonin in serum was determined by the method of enzyme immunoassay (Labor Diagnostica NORT Serotonin RESEARCH ELISA, Germany)

7. Corporal points- 4II, 5II, 11II, 19II, 20II, 15III, 19III, 25III, 36III, 40III, 42III, 45III, 4IV, 6IV, 9IV, 13IV, 14IV, 15IV, 16IV, 3V, 7V, 20VII, 21VII, 62VII, 6IX, 5X,21XI, 41XI, 20XIII, ВМ3. Auricular points– 17, 18, 22, 25, 26а, 28, 34, 37, 39, 45, 51, 55, 84, 87, 82, 95, 96, 100.

9. Dynamics of the level of reactive anxiety (in points) in the process of medical rehabilitation P1-2 – the reliability of the differences between the indicators of group 1 before and after treatment; P3-4 - the reliability of the differences between the indicators of group 2 before and after treatment; P1-3 - the reliability of the differences between indicators before treatment in groups 1 and 2; P2-4 - the reliability of the differences between indicators after treatment in groups 1 and 2.

10. Findings: 1. lower serotonin levels in the blood serum of patients in the observation groups - 173.3 ± 60.8 ng / ml (in the comparison group - 223.9 ± 90.4 ng / ml). 2. The relationship between BMI and serotonin concentration in the serum r = -0.23 (p = 0.04). 3. In group 1 there was an increase in the level of serotonin by 69.5% (p = 0.0057), body weight decreased by 9.8%. 4. In group 2, serotonin levels increased by 34.4% (p = 0.031), and body weight decreased by 7.4% (p = 0.051). 5. Patients of Group 1 after the course of treatment noted a decrease in appetite, which allows to observe the diet and reduce the amount of food.

11. Conclusion • A low serotonin content in the serum of patients with obesity is established. • Dietotherapy in conjunction with reflexology of the auricular and corporal acupuncture points leads to a more pronounced increase in serotonin in the blood serum, compared with the exceptionally traditional diet therapy, which leads to a decrease in appetite and allows to observe hypocaloric diet. • Against the backdrop of the use of reflexotherapy, the positive dynamics of obese patients is much more pronounced, with a clear decrease in appetite, which allows to observe the diet and reduce the amount of food, especially at the initial stage of the treatment.

12. Thank you for attention