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PLANT TOXICOLOGY

THE TOXIC EFFECT OF PLANT. Human: - Baby - Child - Young / adultDomestic animal. THE SOURCE TOXIN OF PLANT.. SPICESMEDICAL HERBVEGETABLES / FRUITS. OXALATCYANIDANITRAT-NITRITPERIRENAL OEDEMATERATOGENIC PLANTSPHOTOSENSITISASI . . OXALATE. SOURCE : Oxalate saltPotasi

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PLANT TOXICOLOGY

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    1. PLANT TOXICOLOGY by : Tutik Juniastuti Dept. KDV - Pharmacology

    2. THE TOXIC EFFECT OF PLANT Human : - Baby - Child - Young / adult Domestic animal

    3. THE SOURCE TOXIN OF PLANT. SPICES MEDICAL HERB VEGETABLES / FRUITS

    4. OXALAT CYANIDA NITRAT-NITRIT PERIRENAL OEDEMA TERATOGENIC PLANTS PHOTOSENSITISASI

    5. OXALATE SOURCE : Oxalate salt Potasium oxalate Oxalate acid Plants to contain Oxalate salt is : Fam. Chenopodiaceae Genus Rumex Araceae Halogeton Sarcobatus (greasea wood) Rheum rhaponticum (Rhubarb) Aspergillus muschroom products, Phenicellium ? nephropaty Ethylenglycol

    6. TOXICITY : Sheep - 0,55% ? if enough of food - 0,1% ? if less of food Horse Ruminansia ? 3 possibility : - destruction in rumen - to bound with Ca ? to precipitate ? to ekskresi with faeces - to absorp ? tissue / to bound with Ca serum

    7. MECHANISM OF ACTION To enter into ? blood ? to bound with blood Ca ? hipocalcemia (tetany) If crystal in blood vessels ? necrose & hemoraghy crystal to precipitate in ren ? anuria, uremia, homeostatic elektrolit desturbed

    8. SYMPTOMA CLINIC 2 - 6 hours Colic - a head to bend Depresi - is not calm Powerless - the position of head is sloping The other of symptom : Breath of fast - blood to foam from mouth Bloat - urinasi frekuent Hypocalcemia ? - convulsion - ? : urea, Na, K, SGOT, SGPT, pH blood - ? : Ca serum, fosfat blood

    9. PATHOLOGIST Ascites hidrotoraks Rum, ret, om ? hemorhagis difus abomasum ? ptechiae Lgg intestin ? to swell Resp tract.: - to dam up - blood to foam in bronchus Ren : - lesi, oedema, capsules to make loose - in slices : the fluid excresi & to be seen the clean is lines (crystal) at cortex & medula border - histopat : (+) crystal oxalat, lat. tub Crystal (+) at wall rumen & brain

    10. DIAGNOSA Clinical history Symptoma Inspection of post mortem Analisis chemistry to contain ofrumen DIF. DIAGNOSA Milk tetany ? pH blood (-) to change of PA is not reliable

    11. THERAPY (+) symptoma clinic ? no effect Infus Ca gluconat Urinary acidifier CONTROL to avoid the plant to contain Oxalat Pellet alfalfa (5% dicalcium fosfat) ? pound daily

    12. CYANIDA = Hydrocyanic acid = Prusic acid SOURCE In plant as glycoside / HCN free Rodentisida, anthelmintic, fumigan Goitrogenic plant Fam. Cruciferae Brasisca spp. Glycine max Linum usitatissinum ? to contain Glycosida tyosianat or 1 5 vinyl 2 thiooxazolidone ? inhibisi hormon tiroid product ? - hiperplastik goiter - s/ hypotiroidism

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