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Etiology of mental disorder. How different between psychiatric disorder and other medical disorders? The Stress-diathesis model The Bio-Psycho-Social modelThe 4Ps modelThe integrative model for case formulation . How different between psychiatric disorder and other medical disorders?. Thai fema
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1. Etiology of mental disorder
Paul Thisayakorn, MD.
2. Etiology of mental disorder How different between psychiatric disorder and other medical disorders?
The Stress-diathesis model
The Bio-Psycho-Social model
The 4Ps model
The integrative model for case formulation
3. How different between psychiatric disorder and other medical disorders? Thai female, 22 y/o
Complaint of Lt.side weakness ,numbness and progressive headache for 1 mo.
Looked cachexia, febrile, cervical LN positive, oral thrush positive ,motor gr.III, decrease pinprick sensation,rt.
Blood profile and CT show the abnormality
Thai female , 22 y/o
Her mother complaint of behavioral change (talk with herself, withdrawn, preoccupy about religion) for 1 mo.
Poor hygiene, poor eye contact ,guarded, and said that she can contact to the ghost and god. She also thought that her friends poisoned her.
PE: normal
Blood profile and CT: normal
4. General approach Problem list (sign& symptom)
Psychiatric problems or not?
What is the psychiatric syndrome?
What is the DSM-IV diagnostic system?
What are the causes of the syndrome?
How to manage this syndrome?
5. Problem list (sign& symptom) Consciousness
Perception
Mood & affect , anxiety
Memory & cognition
Thought (form & content)
intelligence
Motor behavior
6. Problem list (sign& symptom) Disorder or not?
? Use your feeling
? Use your rationale
? Use criteria
8. What is the psychiatric syndrome? Organic mental disorder
Substance use disorder
Psychotic disorder
Mood disorder
Anxiety disorder
Somatoform disorder
Dissociative disorder
Personality disorder
Adjustment disorder
9. What is the DSM-IV diagnostic system? Syndromal approach
Diagnostic criteria
Axis I Axis V
10. Etiology of mental disorder :The history Superstitious, supernatural
Black bile ? melancholia
Unknown neurological symptom
? hysterical conversion
Freud ? intrapsychic problem
The emerging of neurotrophic drug and other modern knowledge
But we still can not completely explain the etiology of the mental disorder!!!
11. The Stress-diathesis model A person may have a specific vulnerability (diathesis)
When acted on by a stressful influence? develop a psychiatric symptom
The difference between individual, character of
stress ? loss of balance
12. The Bio-Psycho-Social model The diathesis or the stress can be biological, psychosocial, environmental or both
Combination of these 3 factors ? disorder
The difference between the severity of Bio-Psycho-Social factors in each person
13. The Bio-Psycho-Social model
Genetic factor ; heterogeneous genetic basis for some mental problems
ex. Alzheimers dementia, Substance use disorder, Schizophrenia, Mood disorders, even homosexuality!!!
14. The Bio-Psycho-Social model Neuropathology
- neuroanatomy and neuroimaging :
frontal lobe, temporal lobe, limbic system (ex.amygdala,hippocampus),
fronto-subcortical circuit etc.
- developmental-degenerative process : childhood mental disorder, Schizophrenia as the dementia precox, psychotic symptoms in dementia pt.
15. Neuropathology
16. The Bio-Psycho-Social model Neuropathology
-neurophysiology ; electrophysiology (psychiatric symptoms in epilepsy, limbic kindling in Bipolar disorder), abnormal sleep-wake cycle in mood disorder
-neurochemistry (neurotransmitter : DA, NE, 5HT, Ach, GABA) ; Dopamine hypothesis in Schizophrenia, Catecholamine abnormality in MDD, decrease of Ach in AD, etc., the efficacy of psychotropic drugs, the effect of substance use
17. The Bio-Psycho-Social model Neuropathology
-neuroendocrinology ; cortisol level in chronic stress person, Hypo-hyperthyroid cause the mental change, Sex hormone related to premenstrual-postpartum symptoms
-neuroimmunology ; stress and immune response (eg. academic stress during final exam among medical students ? low NK cell activity), psychiatric manifestation in SLE, MS
18. The Bio-Psycho-Social model Psychological cause
-psychoanalytic theory : topographic theory (unconscious-preconcious-concious), structural theory (Id-Ego-Superego), Eriksons 8 stages of life cycles
-cognitive-behavioral theory :
stimuli ? sensation ? perception ? thinking ? emotion ? behavior ex. Cognitive triad in depression
19. The Bio-Psycho-Social model Psychological cause
-Existential-humanistic theory ; ex.
loss of meaning of life ? suicide , end of life situation ?
depression, Satirs model
-Personality theory ; ex.
:Schizotypal PD (A) vs. schizophrenia :Antisocial PD (B) vs. alcohol use
:Borderline PD (B) vs. mood disorder
:Histrionic PD (B) vs. somatization disorder
:Avoidant PD (C) vs. anxiety disorder
20. Behavior
Feeling
Thought & perception
Expectation
Yearning
self
21. The Bio-Psycho-Social model Social cause
-Socioeconomic and cultural factors
; a disproportionate number of schizophrenia pts. are in the low socioeconomic groups
(contrastively to Bipolar disorder).
; Social stressors in urban settings affect the development of schizophrenia in persons at risk.
; The stress of immigration ? delusional disorder
; single status as a risk of suicide
22. The Bio-Psycho-Social model Family dynamic ; high expressed emotion in family ? high relapse rate, the impact of family problem to the child (eg. Divorce , loss of parent) , the formation of gender identity and role etc.
Learning theory (classical conditioning, operant conditioning, social learning theory) ex. Phobia & PTSD, learned helplessness vs. depression, aggressive social behavior vs. aggression in children
23. The 4Ps model There are many factors along ones lifetime that may contribute to the mental disorder.
Predisposing factors
Precipitating factors
Perpetuating factors
Protective factors
24. The 4Ps model
25. The case formulation 4Ps X Bio-Psycho-Social ? case formulation
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27. The case formulation
28. Conclusion There are many factors that cause the
mental disorder
One specific factor can not completely explain
these illnesses.
Stress-diathesis model + Bio-Psycho-Social model + 4Ps model help us understand the etiologies of the psychiatric disorders.